ArticleBrain pathology (Zurich, Switzerland)2010
Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*.
Article in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006.Journal of neuro-oncology · 2011Trial
- A brief history of ependymoma.Neuro-oncology · 2026Review
- How is rosette formation in brain tumours linked with cerebrospinal fluid spread?Brain tumor pathology · 2026Review
- Embryonal tumor with multilayered rosettes in a teenager.Autopsy & case reports · 2022Article
- Embryonal tumors with multi-layered rosettes: a disease of dysregulated miRNAs.Journal of neuro-oncology · 2020Review
- Radiation for ETMR: Literature review and case series of patients treated with proton therapy.Clinical and translational radiation oncology · 2019Article
- LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid/Rhabdoid Tumor (AT/RT).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision.Neurologia medico-chirurgica · 2017Review
- Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm.SAGE open medical case reports · 2017Article
- Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR).Journal of neuro-oncology · 2016Review
- Sacrococcygeal ependymoblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified.Neuro-oncology · 2015Article
- MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases.AJNR. American journal of neuroradiology · 2014Article
- Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity.Acta neuropathologica · 2014Article
- CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.Acta neuropathologica · 2014Article
- Embryonal tumor with abundant neuropil and true rosettes: an autopsy case-based update and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).Acta neuropathologica · 2012Article
- Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes.Brain pathology (Zurich, Switzerland) · 2012Article
- Infratentorial medulloepithelioma with divergent differentiation: Possibly a predictor of poor outcome.Journal of pediatric neurosciences · 2012Article
- Ependymoblastoma in an adult: a diagnostic challenge on cytology.BMJ case reports · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ependymoblastoma is a diagnostic label that has been applied to a variety of rare central nervous system (CNS) tumors over the last eight decades. Consequently, there is uncertainty about whether such an entity exists and what its characteristic features might be. The current study, based on 14 cases from our institutional archives and identified by the search terms "ependymoblastoma,"ependymoblastomatous," "ependymoblastic" or "PNET with ependymal differentiation," aimed to test the hypothesis that the ependymoblastoma is a distinct and recognizable entity. Ependymoblastic rosettes are a key diagnostic feature and were present in 11/14 (79%) tumors, eight (73%) of which were embryonal tumors with abundant areas of neuropil-like differentiation. Three other cases showed rare ependymoblastic rosettes in the histopathological setting of a typical primitive neuroectodermal tumor (PNET), medulloblastoma (MB) or atypical teratoid/rhabdoid tumor (AT/RT). The remaining cases were all embryonal tumors with structures that mimicked ependymoblastic rosettes. Our results indicate that ependymoblastic rosettes are most frequently encountered in embryonal tumors with abundant neuropil and less frequently in other CNS embryonal neoplasms, including PNET, MB and AT/RT. We believe that ependymoblastoma as a diagnosis is neither precise nor specific and that it is time once and for all to retire this diagnosis from the lexicon of neuropathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.