Evidence map›Paper›PMID 19120285›Full record

ArticleAnnals of the New York Academy of Sciences2008

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.

David M Miller, Thomas Thornley, Todd Pearson, Masahiro Yamazaki, Michael A Brehm, Aldo A Rossini, Dale L Greiner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. T-cell activation and transplantation tolerance.Transplantation reviews (Orlando, Fla.) · 2012
    Review
  2. HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.International journal of clinical and experimental pathology · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

David M MillerDepartment of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Thomas Thornley
Todd Pearson
Masahiro Yamazaki
Michael A Brehm
Aldo A Rossini
Dale L Greiner
Diabetes Australia · AU

Funding

PILOT AND FEASIBILITY PROGRAMP30DK032520 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2010
$14.6M
SINGLE CYCLE SIV PARTICLES--A NOVEL VACCINE STRATEGYR21AI042669 · NIAID · AARON DIAMOND AIDS RESEARCH CENTER · PI ZHANG, LINQI · 1997 to 1998
–
NIAID NIH HHS AI42669NIDDK NIH HHS DK32520NIDDK NIH HHS P30 DK032520
6 · The paper itself

Abstract

We investigated the mechanisms by which Toll-like receptor (TLR) agonists affect the induction of mixed chimerism and skin allograft survival in mice treated with co-stimulation blockade (CB). We report that TLR agonists prevent the generation of mixed chimerism by breaking tolerance in the alloreactive CD4(+) and CD8(+) T cell compartments, and that type I interferon (IFN) is important in this process. Understanding how environmental perturbations affect CB-induced transplantation tolerance may lead to more effective regimens that can be used as an approach for the treatment of type I diabetes, for which the transplantation of pancreatic islets is a promising therapy.

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChimerismImmunosuppressive AgentsLipopolysaccharidesLymphocyte ActivationMiceMice, KnockoutPoly I-CReceptor, Interferon alpha-betaSkin TransplantationToll-Like Receptor 3Toll-Like Receptor 4Toll-Like ReceptorsTransplantation ToleranceIfnar1 protein, mouseImmunosuppressive AgentsLipopolysaccharidesPoly I-CReceptor, Interferon alpha-betaTLR3 protein, mouseTlr4 protein, mouseToll-Like Receptor 3Toll-Like Receptor 4Toll-Like Receptors

Identifiers

PMID19120285
PMCPMC2626129
OpenAlexW1969280039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.