ReviewAnnals of the New York Academy of Sciences2008
From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases.
Review in Annals of the New York Academy of Sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Clinical characteristics and management of PD-1/PD-L1 inhibitor-induced secondary adrenal insufficiency.Endocrine connections · 2026Article
- Diagnosis and management of presumptive cyclic vomiting syndrome in a dog: first report in veterinary medicine.BMC veterinary research · 2025Article
- Review
- The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives.Frontiers in psychiatry · 2020Review
- Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress.Frontiers in psychiatry · 2020Article
- Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission.Journal of clinical medicine · 2018Review
- Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.Current molecular pharmacology · 2018Review
- Disease-modifying effects of ganglioside GM1 in Huntington's disease models.EMBO molecular medicine · 2017Article
- Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease.Frontiers in immunology · 2017Review
- Corticotropin-Releasing Factor From Rodents to Primates: Translational Hope Expresses Itself, Pun Intended.Biological psychiatry · 2016Article
- The Realization of the Brain-Gut Interactions with Corticotropin-Releasing Factor and Glucocorticoids.Current neuropharmacology · 2016Review
- Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating.Psychoneuroendocrinology · 2015Article
- Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia.Journal of neurogastroenterology and motility · 2015Article
- Corticotrophin-releasing factor 1 activation in the central amygdale and visceral hyperalgesia.Neurogastroenterology and motility · 2015Review
- Insights into the molecular mechanism of glucose metabolism regulation under stress in chicken skeletal muscle tissues.Saudi journal of biological sciences · 2014Review
- Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptors.Journal of gastroenterology · 2014Article
- Article
- Stress and the Stomach: Corticotropin-Releasing Factor May Protect the Gastric Mucosa in Stress Through Involvement of Glucocorticoids.Cellular and molecular neurobiology · 2012Article
- Stress and visceral pain: from animal models to clinical therapies.Experimental neurology · 2012Review
- Brain-Gut Interactions in IBS.Frontiers in pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Selye pioneered the concept of biological stress in 1936, culminating in the identification of the corticotropin-releasing factor (CRF) signaling pathways by Vale's group in the last two decades. The characterization of the 41 amino-acid CRF and other peptide members of the mammalian CRF family, urocortin 1, urocortin 2, and urocortin 3, and the cloning of CRF(1) and CRF(2) receptors, which display distinct affinity for CRF ligands, combined with the development of selective CRF receptor antagonists enable us to unravel the importance of CRF(1) receptor in the stress-related endocrine (activation of pituitary-adrenal axis), behavioral (anxiety/depression, altered feeding), autonomic (activation of sympathetic nervous system), and immune responses. The activation of CRF(1) receptors is also one of the key mechanisms through which various stressors impact the gut to stimulate colonic propulsive motor function and to induce hypersensitivity to colorectal distension as shown by the efficacy of the CRF(1) receptor antagonists in blunting these stress-related components. The importance of CRF(1) signaling pathway in the visceral response to stress in experimental animals provided new therapeutic approaches for treatment of functional bowel disorder such as irritable bowel syndrome, a multifactor functional disorder characterized by altered bowel habits and visceral pain, for which stress has been implicated in the pathophysiology and is associated with anxiety-depression in a subset of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.