ArticleAlcoholism, clinical and experimental research2009
Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior.
Article in Alcoholism, clinical and experimental research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Effect of MAOA rs1465108 polymorphism on susceptibility to substance/alcohol use disorder: a novel PCR-RFLP assay for the detection of MAOA rs1465108.Molecular biology reports · 2024Article
- Sex-dependent factors of alcohol and neuroimmune mechanisms.Neurobiology of stress · 2023Article
- Theorizing the Role of Dopaminergic Polymorphic Risk Alleles with Intermittent Explosive Disorder (IED), Violent/Aggressive Behavior and Addiction: Justification of Genetic Addiction Risk Severity (GARS) Testing.Journal of personalized medicine · 2022Article
- Crime-Specific Recidivism in Criminal Justice Clients with Substance Use-A Cohort Study.International journal of environmental research and public health · 2022Article
- Associations ofArhiv za higijenu rada i toksikologiju · 2021Article
- Alcohol Intoxication Moderates the Association between a Polygenic Risk Score and Unprovoked Intimate Partner Aggression.Journal of family violence · 2018Article
- Does MAOA increase susceptibility to prenatal stress in young children?Neurotoxicology and teratology · 2017Article
- Studying longitudinal trajectories in animal models of psychiatric illness and their translation to the human condition.Neuroscience research · 2016Review
- Alcohol and violence: neuropeptidergic modulation of monoamine systems.Annals of the New York Academy of Sciences · 2015Review
- Article
- Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene-environmentinteractions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR [corrected].The international journal of neuropsychopharmacology · 2014Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Further investigation of genetics and intimate partner violence.Violence against women · 2014Article
- Genetic associations with intimate partner violence in a sample of hazardous drinking men in batterer intervention programs.Violence against women · 2014Article
- The genetic basis of addictive disorders.The Psychiatric clinics of North America · 2012Article
- The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks.Genome biology · 2012Review
- Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.Journal of molecular neuroscience : MN · 2012Article
- Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Psychopathy, PCL-R, and MAOA genotype as predictors of violent reconvictions.Psychiatry research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundEnvironmental factors appear to interact with a functional polymorphism (MAOA-LPR) in the promoter region of the monoamine oxidase A gene (MAOA) in determining some forms of antisocial behavior. However, how MAOA-LPR modulates the effects of other factors such as alcohol consumption related to antisocial behavior is not completely understood.
methodsThis study examines the conjunct effect of MAOA-LPR, alcohol consumption, and aging on the risk for violent behavior. Recidivism in severe impulsive violent behavior was assessed after 7 to 15 years in a sample of 174 Finnish alcoholic offenders, the majority of whom exhibited antisocial or borderline personality disorder or both, and featured impulsive temperament traits.
resultsThe risk for committing new acts of violence increased by 2.3% for each kilogram of increase in yearly mean alcohol consumption (p = 0.004) and decreased by 7.3% for every year among offenders carrying the high activity MAOA genotype. In contrast, alcohol consumption and aging failed to affect violent behavior in the low activity MAOA genotyped offenders. MAOA-LPR showed no main effect on the risk for recidivistic violence.
conclusionsViolent offenders carrying the high activity MAOA genotype differ in several ways from carriers with the low activity MAOA risk allele previously associated with antisocial behavior. Finnish high activity MAOA genotyped risk alcoholics exhibiting antisocial behavior, high alcohol consumption, and abnormal alcohol-related impulsive and uncontrolled violence might represent an etiologically distinct alcohol dependence subtype.
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