Evidence map›Paper›PMID 19119264›Full record

ReviewNature reviews. Genetics2009

Fundamental concepts in genetics: genetics and the understanding of selection.

Laurence D Hurst

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Organizational Principles of the Primate Cerebral Cortex at the Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Comparative Analyses of the Complete Mitogenomes of TwoInternational journal of molecular sciences · 2024
    Article
  9. Natural Course ofChildren (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Comparing Clinical and Genetic Characteristics ofFrontiers in endocrinology · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Emotional Theory of Rationality.Frontiers in integrative neuroscience · 2019
    Article
  19. New insights into the evolution of wheat avenin-like proteins in wild emmer wheat (Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Laurence D HurstDepartment of Biology and Biochemistry, University of Bath, Somerset, BA2 7AY, UK. l.d.hurst@bath.ac.uk

Funding

Medical Research Council G0300415
6 · The paper itself

Abstract

At first sight selection is a simple notion, and some consider it the most important evolutionary force. But how important is selection, is it really so trivial to understand and what are the alternatives? Here I discuss how genetics is crucial for addressing all of these questions: genetics allowed the concept of natural selection to become viable, it contributed to our understanding of the complexities of selection and it spurred the development of competing models of evolution. Understanding how and why selection acts has important potential applications, from understanding the mechanisms of disease and microbial resistance, to improving the design of transgenes and drugs.

Indexed as

AllelesGenetics, PopulationSelection, GeneticInheritance PatternsLinkage Disequilibrium

Identifiers

PMID19119264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.