ReviewMethods in cell biology2008
Chapter 10: Infrared and Raman microscopy in cell biology.
Review in Methods in cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed.
- Combined Approach of Chromatographic Fractionation and Raman Spectroscopy for Metabolite Profiling ofInternational journal of molecular sciences · 2026Article
- Perspectives on label-free microscopy of heterogeneous and dynamic biological systems.Journal of biomedical optics · 2025Article
- Posthandling Spectral Information Enhancement for Single Cell Raman Molecular Mapping Analysis.Analytical chemistry · 2025Article
- Effects of biological fixation methods on stimulated Raman scattering microscopy signal.bioRxiv : the preprint server for biology · 2025Article
- Combining quantum cascade lasers and plasmonic metasurfaces to monitorNanophotonics (Berlin, Germany) · 2025Article
- Characterization of Rhesus Macaque Embryonic Stem Cells in Primed and Naïve-like Cell States of Pluripotency Using Fourier Transform Infrared (FTIR) Microspectroscopy.International journal of molecular sciences · 2025Article
- Noninvasive Analysis of Biological Components Using Simplified Mid-Infrared Photothermal Deflection Spectroscopy.Sensors (Basel, Switzerland) · 2025Article
- Machine learning with label-free Raman microscopy to investigate ferroptosis in comparison with apoptosis and necroptosis.Communications biology · 2025Article
- Observation of biological and emulsion samples by newly developed three-dimensional impedance scanning electron microscopy.Computational and structural biotechnology journal · 2024Article
- A Study of the Association between Primary Oral Pathologies (Dental Caries and Periodontal Diseases) Using Synchrotron Molecular FTIR Spectroscopy in View of the Patient's Personalized Clinical Picture (Demographics and Anamnesis).International journal of molecular sciences · 2024Article
- Statistical estimation theory detection limits for label-free imaging.Journal of biomedical optics · 2024Article
- Single virus fingerprinting by widefield interferometric defocus-enhanced mid-infrared photothermal microscopy.Nature communications · 2023Article
- Quick Detection ofSensors (Basel, Switzerland) · 2023Article
- Spatiotemporal Heterogeneity of De Novo Lipogenesis in Fixed and Living Single Cells.The journal of physical chemistry. B · 2023Article
- Structural analysis of melanosomes in living mammalian cells using scanning electron-assisted dielectric microscopy with deep neural network.Computational and structural biotechnology journal · 2023Article
- A Review on Data Fusion of Multidimensional Medical and Biomedical Data.Molecules (Basel, Switzerland) · 2022Review
- Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study.Pharmaceutics · 2022Article
- Label-free, non-invasive, and repeatable cell viability bioassay using dynamic full-field optical coherence microscopy and supervised machine learning.Biomedical optics express · 2022Article
- Evaluation of Controlled Ovarian Stimulation Protocols in Patients with Normal and Low Ovarian Reserve: Analyses of miRNAs and Selected Target Genes Involved in the Proliferation of Human Cumulus Cells and Oocyte Quality.International journal of molecular sciences · 2022Article
- Coherent anti-Stokes Raman scattering cell imaging and segmentation with unsupervised data analysis.Frontiers in cell and developmental biology · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
This chapter presents novel microscopic methods to monitor cell biological processes of live or fixed cells without the use of any dye, stains, or other contrast agent. These methods are based on spectral techniques that detect inherent spectroscopic properties of biochemical constituents of cells, or parts thereof. Two different modalities have been developed for this task. One of them is infrared micro-spectroscopy, in which an average snapshot of a cell's biochemical composition is collected at a spatial resolution of typically 25 mum. This technique, which is extremely sensitive and can collect such a snapshot in fractions of a second, is particularly suited for studying gross biochemical changes. The other technique, Raman microscopy (also known as Raman micro-spectroscopy), is ideally suited to study variations of cellular composition on the scale of subcellular organelles, since its spatial resolution is as good as that of fluorescence microscopy. Both techniques exhibit the fingerprint sensitivity of vibrational spectroscopy toward biochemical composition, and can be used to follow a variety of cellular processes.
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