Evidence map›Paper›PMID 19118665›Full record

ArticleCurrent topics in developmental biology2008

Drosophila germline sex determination: integration of germline autonomous cues and somatic signals.

Leonie U Hempel, Rasika Kalamegham, John E Smith, Brian Oliver

Abstract read
In one paragraph

Article in Current topics in developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Targeted mutagenesis of specific genomic DNA sequences in animals for thebioRxiv : the preprint server for biology · 2024
    Article
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  6. Article
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  8. Article
  9. Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leonie U HempelLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
Rasika Kalamegham
John E Smith
Brian Oliver

Funding

Drosophila Functional GenomicsZIADK015600 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI OLIVER, BRIAN · 2009 to 2025
$23.9M
GERMLINE SEX DETERMINATIONZ01DK015600 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI OLIVER, BRIAN C · 1996 to 2008
$949k
Drosophila Germline DevelopmentZ01DK015608 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI OLIVER, BRIAN · 2007 to 2008
$659k
Intramural NIH HHS Z01 DK015600
6 · The paper itself

Abstract

The Drosophila testis and ovary are major genetically tractable systems for studying stem cells and their regulation. This has resulted in a deep understanding of germline stem cell regulation by the microenvironment, or niche. The male and female germline niches differ. Since sex is determined through different mechanisms in the soma than in the germline, genetic or physical manipulations can be used to experimentally mismatch somatic and germline sexual identities. The phenotypic consequences of these mismatches have striking similarities to those resulting from manipulations of signals within the niche. A critical role of the germline sex determination pathway may therefore be to ensure the proper receipt and processing of signals from the niche.

Indexed as

Sex Determination ProcessesSex DifferentiationSignal TransductionAnimalsCell ProliferationDrosophilaFemaleGerm CellsMale

Identifiers

PMID19118665
PMCPMC8934111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.