ArticleDevelopmental biology2009
Functions of Fyn kinase in the completion of meiosis in mouse oocytes.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Fertility considerations in targeted biologic therapy with tyrosine kinase inhibitors: a review.Journal of assisted reproduction and genetics · 2021Review
- A genome-wide scan of copy number variants in three Iranian indigenous river buffaloes.BMC genomics · 2021Article
- Metabolism-associated genome-wide epigenetic changes in bovine oocytes during early lactation.Scientific reports · 2020Article
- Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis.Molecular reproduction and development · 2014Article
- Effects of dimethyl sulfoxide on asymmetric division and cytokinesis in mouse oocytes.BMC developmental biology · 2014Article
- Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression.Fertility and sterility · 2014Article
- SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective.Advances in experimental medicine and biology · 2014Review
- Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia.PloS one · 2012Article
- Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes.Molecular reproduction and development · 2011Article
- Mammalian oocytes are targets for prostaglandin E2 (PGE2) action.Reproductive biology and endocrinology : RB&E · 2010Article
- Pharmacological analyses of protein kinases regulating egg maturation in marine nemertean worms: a review and comparison with Mammalian eggs.Marine drugs · 2010Review
- The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation.PloS one · 2010Article
- Dynamics of protein phosphorylation during meiotic maturation.Journal of assisted reproduction and genetics · 2010Article
- Role of Fyn kinase in oocyte developmental potential.Reproduction, fertility, and development · 2010Article
- Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex.Molecular reproduction and development · 2009Article
- Protein tyrosine kinase signaling during oocyte maturation and fertilization.Molecular reproduction and developmentReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Oocyte maturation invokes complex signaling pathways to achieve cytoplasmic and nuclear competencies for fertilization and development. The Src-family kinases FYN, YES and SRC are expressed in mammalian oocytes but their function during oocyte maturation remains an open question. Using chemical inhibitor, siRNA knockdown, and gene deletion strategies the function of Src-family kinases was evaluated in mouse oocytes during maturation under in vivo and in vitro conditions. Suppression of Src-family as a group with SKI606 greatly reduced meiotic cell cycle progression to metaphase-II. Knockdown of FYN kinase expression after injection of FYN siRNA resulted in an approximately 50% reduction in progression to metaphase-II similar to what was observed in oocytes isolated from FYN (-/-) mice matured in vitro. Meiotic cell cycle impairment due to a Fyn kinase deficiency was also evident during oocyte maturation in vivo since ovulated cumulus oocyte complexes collected from FYN (-/-) mice included immature metaphase-I oocytes (18%). Commonalities in meiotic spindle and chromosome alignment defects under these experimental conditions demonstrate a significant role for Fyn kinase activity in meiotic maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.