ArticleBiochemical and biophysical research communications2009
Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells.
Article in Biochemical and biophysical research communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Butyrate reduces adherent-invasiveGut microbes · 2023Article
- Review
- The global succinylation of SARS-CoV-2-infected host cells reveals drug targets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa.Molecular vision · 2021Article
- A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons.Neuroscience · 2020Article
- Natural products, PGC-1Acta pharmaceutica Sinica. B · 2020Review
- COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm.Oxidative medicine and cellular longevity · 2020Review
- Role of mitochondria in diabetic peripheral neuropathy: Influencing the NADInternational review of neurobiology · 2019Review
- Cell-Specific Deletion of PGC-1α from Medium Spiny Neurons Causes Transcriptional Alterations and Age-Related Motor Impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons.Molecular neurobiology · 2016Article
- PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.Neuroscience · 2014Article
- Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts.Molecular genetics and metabolism · 2014Article
- PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy.Neurobiology of disease · 2014Article
- Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia.Frontiers in behavioral neuroscience · 2013Review
- Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain.Neuroscience letters · 2013Article
- Mitochondria and PGC-1α in Aging and Age-Associated Diseases.Journal of aging research · 2011Article
- Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1alpha.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Recent evidence suggests that the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC-1alpha) is involved in the pathology of Huntington's Disease (HD). While animals lacking PGC-1alpha express lower levels of genes involved in antioxidant defense and oxidative phosphorylation in the brain, little is known about other targets for PGC-1alpha in neuronal cells and whether there are ways to pharmacologically target PGC-1alpha in neurons. Here, PGC-1alpha overexpression in SH-SY5Y neuroblastoma cells upregulated expression of genes involved in mitochondrial function, glucose transport, fatty acid metabolism, and synaptic function. Overexpression also decreased vulnerability to hydrogen peroxide-induced cell death and caspase 3 activation. Treatment of cells with the histone deacetylase inhibitors (HDACi's) trichostatin A and valproic acid upregulated PGC-1alpha and glucose transporter 4 (GLUT4). These results suggest that PGC-1alpha regulates multiple pathways in neurons and that HDACi's may be good candidates to target PGC-1alpha and GLUT4 in HD and other neurological disorders.
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Registered trials
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