ArticleChest2009
Oxidative damage to nucleic acids in severe emphysema.
Article in Chest, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 78 citations in OpenAlex.
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- The post-viral GPNMBmedRxiv : the preprint server for health sciences · 2024Article
- MAPK13 controls structural remodeling and disease after epithelial injury.bioRxiv : the preprint server for biology · 2024Article
- Molecular changes underlying pulmonary emphysema and chronic bronchitis in Chronic Obstructive Pulmonary Disease: An updated review.Histology and histopathology · 2024Review
- Lung Remodeling Regions in Long-Term Coronavirus Disease 2019 Feature Basal Epithelial Cell Reprogramming.The American journal of pathology · 2023Article
- Lung microhaemorrhage drives oxidative/inflammatory damage in αERJ open research · 2023Article
- Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming.medRxiv : the preprint server for health sciences · 2022Article
- Selective Imaging of Lung Macrophages Using [Molecular imaging and biology · 2021Article
- The Beneficial Effects of Antioxidants in Health And Diseases.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2020Review
- The ageing lung under stress.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension.Cardiovascular research · 2018Review
- Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development.American journal of respiratory cell and molecular biology · 2018Article
- Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease.Oxidative medicine and cellular longevity · 2018Review
- Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review.Frontiers in immunology · 2017Review
- 8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging.Mechanisms of ageing and development · 2017Article
- Oxidative Stress Markers in Sputum.Oxidative medicine and cellular longevity · 2016Review
- The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma.Mediators of inflammation · 2016Review
- 8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: role in asthma pathogenesis.Current opinion in allergy and clinical immunology · 2015Review
- Myb permits multilineage airway epithelial cell differentiation.Stem cells (Dayton, Ohio) · 2014Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs.
methodsThirteen human severe emphysematous lungs, including five with alpha(1)-antitrypsin deficiency (AATD), were obtained from patients receiving lung transplantation. Control lung tissue was obtained from non-COPD lungs (n = 8) and donor lungs (n = 8). DNA and RNA oxidation were investigated by immunochemistry. Morphometry (mean linear intercept [Lm] and CT scan) and immunostaining for CD68 and neutrophil elastase also were performed.
resultsNucleic acid oxidation was increased in alveolar wall cells in emphysematous lungs compared to non-COPD and donor lungs (p < 0.01). In emphysematous lungs, oxidative damage to nucleic acids in alveolar wall cells was increased in the more severe emphysematous areas assessed by histology (Lm, > 0.5 mm; p < 0.05) and CT scan (< -950 Hounsfield units; p < 0.05). Compared to classic emphysema, AATD lungs exhibited higher levels of nucleic acid oxidation in macrophages (p < 0.05) and airway epithelial cells (p < 0.01). Pretreatments with DNase and RNase demonstrated that RNA oxidation was more prevalent than DNA oxidation in alveolar wall cells.
conclusionsWe demonstrated for the first time that nucleic acids, especially RNA, are oxidized in human emphysematous lungs. The correlation between the levels of oxidative damage to nucleic acids in alveolar wall cells and the severity of emphysema suggest a potential role in the pathogenesis of emphysema.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.