ReviewJournal of cell science2009
Integrins in mammary-stem-cell biology and breast-cancer progression--a role in cancer stem cells?
Review in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Molecular Biology Mechanisms and Emerging Therapeutics of Triple-Negative Breast Cancer.Biologics : targets & therapy · 2023Review
- Article
- Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications.Pharmacology & therapeutics · 2022Review
- Fate decisions of breast cancer stem cells in cancer progression.Frontiers in oncology · 2022Review
- Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models.International journal of pharmaceutics · 2021Article
- Differences and similarities between cancer and somatic stem cells: therapeutic implications.Stem cell research & therapy · 2020Review
- Anticancer Actions of Azurin and Its Derived Peptide p28.The protein journal · 2020Review
- iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity.Journal of nanobiotechnology · 2019Article
- Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis.The Analyst · 2019Article
- Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance.Stem cells international · 2019Review
- Isolation and characterization of adult mammary stem cells from breast cancer-adjacent tissues.Oncology letters · 2017Article
- Article
- Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.Nature reviews. Clinical oncology · 2016Review
- Modulation of membrane properties of lung cancer cells by azurin enhances the sensitivity to EGFR-targeted therapy and decreased β1 integrin-mediated adhesion.Cell cycle (Georgetown, Tex.) · 2016Article
- Importance of Interaction between Integrin and Actin Cytoskeleton in Suspension Adaptation of CHO cells.Applied biochemistry and biotechnology · 2016Article
- Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.Genes & development · 2016Article
- Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells.Cancer cell international · 2016Article
- Mitochondria as therapeutic targets for cancer stem cells.World journal of stem cells · 2015Review
- A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers.Epigenetics · 2015Article
- P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells.Oncotarget · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer cells with stem cell-like properties (cancer stem cells) are believed to drive cancer and are associated with poor prognosis. Data from mouse models have demonstrated that integrins, the major cellular receptors for extracellular-matrix components, have essential roles both during cancer initiation and progression, and during cell differentiation in normal development. By presenting an overview of the role of integrins in stem-cell biology and in cancer progression, this Commentary aims to present evidence for a role of integrins in the biology of cancer stem cells. Given the recent interest in the role of integrins in breast-cancer initiation and progression, we focus on the role of the members of the integrin family and their coupled signaling pathways in mammary-gland development and tumorigenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.