ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03512171 (Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults), which is not on this map. Cited by 108 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults
Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it, 234 citations in OpenAlex.
- The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis.Progress in neurobiology · 2015Pooled it
- Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults.Alcohol, clinical & experimental research · 2023Trial
- Trial
- Amphetamine-induced dopamine release and impulsivity in Parkinson's disease.Brain : a journal of neurology · 2022Trial
- The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor.Psychiatry research · 2022Trial
- A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder.Brain : a journal of neurology · 2018Trial
- Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.Psychopharmacology · 2016Trial
- A pilot study of women's affective responses to common and uncommon forms of aerobic exercise.Psychology & health · 2016Trial
- Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making.Scientific reports · 2015Trial
- Levodopa administration modulates striatal processing of punishment-associated items in healthy participants.Psychopharmacology · 2015Trial
- D2 autoreceptors gate vulnerability to cocaine use disorder.bioRxiv : the preprint server for biology · 2026Article
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Exploring the link between personality dimensions and non-motor fluctuations in Parkinson's disease.Journal of Parkinson's disease · 2025Article
- The influence of dopamine autoreceptors on temperament and addiction risk.Neuroscience and biobehavioral reviews · 2023Review
- Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023Article
- Novelty exposure induces stronger sensorimotor representations during a manual adaptation task.Annals of the New York Academy of Sciences · 2022Article
- Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward.Cognitive, affective & behavioral neuroscience · 2022Article
- Mitragynine improves cognitive performance in morphine-withdrawn rats.Psychopharmacology · 2022Article
- Personality characteristics and medical impact of stimulant laxative abuse in eating disorder patients-a pilot study.Journal of eating disorders · 2021Article
- Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.Biological psychiatry · 2021Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Novelty-seeking personality traits are a major risk factor for the development of drug abuse and other unsafe behaviors. Rodent models of temperament indicate that high novelty responding is associated with decreased inhibitory autoreceptor control of midbrain dopamine neurons. It has been speculated that individual differences in dopamine functioning also underlie the personality trait of novelty seeking in humans. However, differences in the dopamine system of rodents and humans, as well as the methods for assessing novelty responding/seeking across species leave unclear to what extent the animal models inform our understanding of human personality. In the present study we examined the correlation between novelty-seeking traits in humans and D(2)-like (D(2)/D(3)) receptor availability in the substantia nigra/ventral tegmental area. Based on the rodent literature we predicted that novelty seeking would be characterized by lowered levels of D(2)-like (auto)receptor availability in the midbrain. Thirty-four healthy adults (18 men, 16 women) completed the Tridimensional Personality Questionnaire-Novelty-Seeking Scale and PET scanning with the D(2)/D(3) ligand [(18)F]fallypride. Novelty-Seeking personality traits were inversely associated with D(2)-like receptor availability in the ventral midbrain, an effect that remained significant after controlling for age. We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.