ArticleClinical journal of the American Society of Nephrology : CJASN2009
Association of markers of iron stores with outcomes in patients with nondialysis-dependent chronic kidney disease.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Association of Intravenous Versus Oral Iron Therapy With Clinical Outcomes in Patients With Advanced CKD.Kidney medicine · 2026Article
- Associations between iron markers with hemoglobin and outcomes in peritoneal dialysis patients: results from the PDTAP study.Clinical kidney journal · 2025Article
- The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease.Kidney research and clinical practice · 2024Article
- Association of oral iron replacement therapy with kidney failure and mortality in CKD patients.Clinical kidney journal · 2023Article
- Association between iron status markers and kidney outcome in patients with chronic kidney disease.Scientific reports · 2023Article
- The Association between Iron Deficiency and Renal Outcomes Is Modified by Sex and Anemia in Patients with Chronic Kidney Disease Stage 1-4.Journal of personalized medicine · 2023Article
- Protein Energy Wasting in a Cohort of Maintenance Hemodialysis Patients in Dhaka, Bangladesh.Nutrients · 2022Article
- Serum Biomarkers of Iron Stores Are Associated with Increased Risk of All-Cause Mortality and Cardiovascular Events in Nondialysis CKD Patients, with or without Anemia.Journal of the American Society of Nephrology : JASN · 2021Article
- FGF23 and Cause-Specific Mortality in Community-Living Individuals-The Health, Aging, and Body Composition Study.Journal of the American Geriatrics Society · 2021Article
- Intact and C-Terminal FGF23 Assays-Do Kidney Function, Inflammation, and Low Iron Influence Relationships With Outcomes?The Journal of clinical endocrinology and metabolism · 2020Article
- Systemic inflammation modulates the ability of serum ferritin to predict all-cause and cardiovascular mortality in peritoneal dialysis patients.BMC nephrology · 2020Article
- Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.Nutrients · 2018Review
- Safety concerns about intravenous iron therapy in patients with chronic kidney disease.Clinical kidney journal · 2016Review
- Association between Serum Ferritin and Contrast-Induced Nephropathy in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.BioMed research international · 2016Observational
- Lipids, blood pressure and kidney update 2015.Lipids in health and disease · 2015Review
- Ferritin as a predictor of decline in residual renal function in peritoneal dialysis patients.The Korean journal of internal medicine · 2014Observational
- Article
- Association of hsCRP, white blood cell count and ferritin with renal outcome in chronic kidney disease patients.PloS one · 2012Article
- Correction of iron deficiency in the cardiorenal syndrome.International journal of nephrology · 2011Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesAssessments of iron stores by serum iron saturation ratio (ISAT) and ferritin are used to direct anemia therapy in chronic kidney disease (CKD) and are associated with clinical outcomes in patients on dialysis. The association of ISAT and ferritin with outcomes in patients with nondialysis-dependent CKD (NDD-CKD) has not been studied. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All-cause mortality and progression of CKD [slopes of estimated GFR (eGFR)] were examined in 453 men with NDD-CKD. Mortality and the composite of mortality and ESRD were studied in Cox models. Slopes of eGFR were examined in mixed-effects models.
resultsLower ISAT was associated with higher mortality; adjusted hazard ratio [95% confidence interval (CI)] with ISAT of <12%, 13 to 17%, and >23% versus 18 to 23%; 1.40 (0.99 to 1.98), 1.20 (0.82 to 1.76), and 0.97 (0.67 to 1.41), P = 0.025 for trend. ISAT was also associated with steeper slopes of eGFR (one log-unit higher ISAT associated with a slope of -0.89 ml/min/1.73 m(2) /yr (95% CI: -1.75, -0.02, P = 0.044). Serum ferritin level showed no significant association with outcomes overall, but a trend for higher mortality was observed in patients with a serum ferritin level >250 ng/ml.
conclusionsHigher ISAT is associated with lower mortality and with more progressive CKD. Clinical trials are needed to examine if correction of low iron levels can improve mortality without affecting kidney function in NDD-CKD.
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