ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning.BMC veterinary research · 2015Trial
- Prognostic model development for classification of colorectal adenocarcinoma by using machine learning model based on feature selection technique boruta.Scientific reports · 2023Article
- Purified PEGylated human glucagon-like peptide-2 reduces the severity of irradiation-induced acute radiation enteritis in rats.Journal of radiation research · 2019Article
- Host-Gut Microbiota Crosstalk in Intestinal Adaptation.Cellular and molecular gastroenterology and hepatology · 2018Review
- Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition.Cellular and molecular gastroenterology and hepatology · 2017Article
- Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids.Biology open · 2015Article
- Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: translational relevance and challenges.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon.PloS one · 2013Article
- Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration.PloS one · 2013Article
- Hyaluronic acid regulates normal intestinal and colonic growth in mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Insulin-like growth factor 1: common mediator of multiple enterotrophic hormones and growth factors.Current opinion in gastroenterology · 2012Review
- Article
- Role of intestinal inflammation as an early event in obesity and insulin resistance.Current opinion in clinical nutrition and metabolic care · 2011Review
- Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.Endocrinology · 2011Article
- Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Growth factors: possible roles for clinical management of the short bowel syndrome.Seminars in pediatric surgery · 2010Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Expansion of intestinal progenitors and putative stem cells (pISC) occurs early and transiently following ileo-cecal resection (ICR). The mechanism controlling this process is not defined. We hypothesized that glucagon-like peptide-2 (GLP-2) would augment jejunal pISC expansion only when administered to mice immediately after ICR. Since recent reports demonstrated increases in intestinal insulin-like growth factor (IGF)-I following GLP-2 administration, we further hypothesized that increased intestinal IGF-I expression would correlate with pISC expansion following ICR. To assess this, GLP-2 or vehicle was administered to mice either immediately after resection (early) or before tissue harvest 6 wk following ICR (late). Histological analysis quantified proliferation and intestinal morphometrics. Serum levels of GLP-2 were measured by ELISA and jejunal IGF-I mRNA by qRT-PCR. Expansion of jejunal pISC was assessed by fluorescent-activated cell sorting of side population cells, immunohistochemistry for phosphorylated beta-catenin at serine 552 (a pISC marker), percent of crypt fission, and total numbers of crypts per jejunal circumference. We found that early but not late GLP-2 treatment after ICR significantly augmented pISC expansion. Increases in jejunal IGF-I mRNA correlated temporally with early pISC expansion and effects of GLP-2. Early GLP-2 increased crypt fission and accelerated adaptive increases in crypt number and intestinal caliber. GLP-2 increased proliferation and intestinal morphometrics in all groups. This study shows that, in mice, GLP-2 promotes jejunal pISC expansion only in the period immediately following ICR. This is associated with increased IGF-I and accelerated adaptive increases in mucosal mass. These data provide clinical rationale relevant to the optimal timing of GLP-2 in patients with intestinal failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.