ArticleCancer research2009
The origins of breast cancer prognostic gene expression profiles.
Article in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value.BMC cancer · 2015Pooled it
- A data similarity-based strategy for meta-analysis of transcriptional profiles in cancer.PloS one · 2013Pooled it
- Article
- Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment.Breast cancer research : BCR · 2021Article
- Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo.Oncogene · 2021Review
- How to Choose a Mouse Model of Breast Cancer, a Genomic Perspective.Journal of mammary gland biology and neoplasia · 2019Review
- Integrated landscape of copy number variation and RNA expression associated with nodal metastasis in invasive ductal breast carcinoma.Oncotarget · 2018Article
- Genetic insights into the morass of metastatic heterogeneity.Nature reviews. Cancer · 2018Review
- Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients.PloS one · 2018Article
- Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.PLoS genetics · 2016Article
- The role of individual inheritance in tumor progression and metastasis.Journal of molecular medicine (Berlin, Germany) · 2015Review
- NF-κB gene signature predicts prostate cancer progression.Cancer research · 2014Article
- An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease.Genome research · 2014Article
- Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.Neoplasia (New York, N.Y.) · 2012Article
- Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.PLoS genetics · 2012Article
- Integrated cross-species transcriptional network analysis of metastatic susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.Breast cancer research : BCR · 2011Article
- Gene expression profiles of estrogen receptor-positive and estrogen receptor-negative breast cancers are detectable in histologically normal breast epithelium.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Article
- Variants on the promoter region of PTEN affect breast cancer progression and patient survival.Breast cancer research : BCR · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent high profile clinical trials show that microarray-based gene expression profiling has the potential to become an important tool for predicting prognosis in breast cancer. Earlier work in our laboratory using mouse models and human breast cancer populations has enabled us to show that metastasis susceptibility is an inherited trait. This same combined approach facilitated the identification of a number of candidate genes that, when dysregulated, have the potential to induce prognostic gene expression profiles in human data sets. To investigate if these gene expression signatures were of somatic or germline origin and to assess the contribution of different cell types to the induction of these signatures, we have performed a series of expression profiling experiments in a mouse model of metastatic breast cancer. These results show that both the tumor epithelium and invading stromal tissues contribute to the development of prognostic gene signatures. Furthermore, analysis of normal tissues and tumor transplants suggests that prognostic signatures result from both somatic and inherited components, with the inherited components being more consistently predictive.
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Registered trials
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