ArticleLearning & memory (Cold Spring Harbor, N.Y.)2009
Circadian modulation of short-term memory in Drosophila.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- A Protocol to Assess Time-of-Day-Dependent Learning and Memory in Mice Using the Novel Object Recognition Test.Bio-protocol · 2025Article
- The circadian genes are required in DAL neurons forFrontiers in neuroscience · 2025Article
- Tango-seq: overlaying transcriptomics on connectomics to identify neurons downstream ofbioRxiv : the preprint server for biology · 2024Article
- Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation.Journal of biological rhythms · 2023Article
- Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila.Nature communications · 2023Article
- Circadian disruption of memory consolidation inFrontiers in systems neuroscience · 2023Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic CaMKII Enrichment and Nighttime Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Environmental enrichment decreases anxiety-like behavior in zebrafish larvae.Developmental psychobiology · 2022Article
- Central and Peripheral Clock Control of Circadian Feeding Rhythms.Journal of biological rhythms · 2021Article
- Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.Nature communications · 2021Article
- Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.Cellular and molecular life sciences : CMLS · 2021Review
- Neonicotinoids disrupt memory, circadian behaviour and sleep.Scientific reports · 2021Article
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- The Power ofFrontiers in physiology · 2021Review
- Regulation of Olfactory Associative Memory by the Circadian Clock Output Signal Pigment-Dispersing Factor (PDF).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency.Journal of pineal research · 2019Article
- Contribution of non-circadian neurons to the temporal organization of locomotor activity.Biology open · 2019Article
- The clock gene period differentially regulates sleep and memory in Drosophila.Neurobiology of learning and memory · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous biological clocks are widespread regulators of behavior and physiology, allowing for a more efficient allocation of efforts and resources over the course of a day. The extent that different processes are regulated by circadian oscillators, however, is not fully understood. We investigated the role of the circadian clock on short-term associative memory formation using a negatively reinforced olfactory-learning paradigm in Drosophila melanogaster. We found that memory formation was regulated in a circadian manner. The peak performance in short-term memory (STM) occurred during the early subjective night with a twofold performance amplitude after a single pairing of conditioned and unconditioned stimuli. This rhythm in memory is eliminated in both timeless and period mutants and is absent during constant light conditions. Circadian gating of sensory perception does not appear to underlie the rhythm in short-term memory as evidenced by the nonrhythmic shock avoidance and olfactory avoidance behaviors. Moreover, central brain oscillators appear to be responsible for the modulation as cryptochrome mutants, in which the antennal circadian oscillators are nonfunctional, demonstrate robust circadian rhythms in short-term memory. Together these data suggest that central, rather than peripheral, circadian oscillators modulate the formation of short-term associative memory and not the perception of the stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.