Trial reportPediatrics2009
Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection.
Trial report in Pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 125 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Follow-up Visit of High Risk Infants
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)
Lactoferrin Infant Feeding Trial - LIFT_Canada
Who cites it
125 citing papers in PubMed, 14 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Neurodevelopmental outcomes of preterm with necrotizing enterocolitis: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants: A Systematic Review and Meta-analysis.JAMA pediatrics · 2020Pooled it
- Early erythropoiesis-stimulating agents in preterm or low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- C-reactive protein for diagnosing late-onset infection in newborn infants.The Cochrane database of systematic reviews · 2019Pooled it
- Long-Term Cognitive Outcomes After Sepsis: a Translational Systematic Review.Molecular neurobiology · 2019Pooled it
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Early erythropoiesis-stimulating agents in preterm or low birth weight infants.The Cochrane database of systematic reviews · 2017Pooled it
- Early planned removal of umbilical venous catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2017Pooled it
- Early removal versus expectant management of central venous catheters in neonates with bloodstream infection.The Cochrane database of systematic reviews · 2016Pooled it
- Percutaneous central venous catheters versus peripheral cannulae for delivery of parenteral nutrition in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants.The Cochrane database of systematic reviews · 2015Pooled it
- Antibiotic lock for the prevention of catheter-related infection in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- Efficacy of interventions to improve hand hygiene compliance in neonatal units: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Pooled it
- Study draft: "UVC-You Will See" study: longer vs. shorter umbilical venous catheter (UVC) dwell time (6-10 vs. 1-5 days) in very premature infants with birth weight < 1250 g and/or gestational age < 30 weeks.Wiener medizinische Wochenschrift (1946) · 2024Trial
- Maternal hypertensive disorders and survival without major morbidities among extremely low gestation newborns.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT.Health technology assessment (Winchester, England) · 2020Trial
- Cost-effectiveness of strategies preventing late-onset infection in preterm infants.Archives of disease in childhood · 2020Trial
- Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial.Lancet (London, England) · 2019Trial
- Trial
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveA count of 3 neonatal morbidities (bronchopulmonary dysplasia, brain injury, and severe retinopathy of prematurity) strongly predict the risk of death or neurosensory impairment in extremely low birth weight infants who survive to 36 weeks' postmenstrual age. Neonatal infection has also been linked with later impairment. We examined whether the addition of infection to the count of 3 neonatal morbidities further improves the prediction of poor outcome.
methodsWe studied 944 infants who participated in the Trial of Indomethacin Prophylaxis in Preterms and survived to 36 weeks' postmenstrual age. Culture-proven sepsis, meningitis, and stage II or III necrotizing enterocolitis were recorded prospectively. We investigated the incremental prognostic importance of neonatal infection by adding terms for the different types of infection to a logistic model that already contained terms for the count of bronchopulmonary dysplasia, brain injury, and severe retinopathy. Poor outcome at 18 months of age was death or survival with 1 or more of the following: cerebral palsy, cognitive delay, severe hearing loss, and bilateral blindness.
resultsThere were 414 (44%) infants with at least 1 episode of infection or necrotizing enterocolitis. Meningitis and the presence of any type of infection added independent prognostic information to the morbidity-count model. The odds ratio associated with infection or necrotizing enterocolitis in this model was 50% smaller than the odds ratio associated with each count of the other 3 neonatal morbidities. Meningitis was rare and occurred in 22 (2.3%) of 944 infants.
conclusionsIn this cohort of extremely low birth weight infants who survived to 36 weeks' postmenstrual age, neonatal infection increased the risk of a late death or survival with neurosensory impairment. However, infection was a weaker predictor of poor outcome than bronchopulmonary dysplasia, brain injury, and severe retinopathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.