ReviewAdvances in immunology2008
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.
Review in Advances in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- The IgHFrontiers in immunology · 2023Article
- Review
- An Erg-driven transcriptional program controls B cell lymphopoiesis.Nature communications · 2020Article
- Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia.Nature communications · 2019Article
- The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination.Molecular cell · 2018Article
- Epigenetic modifications of the VImmunology · 2017Article
- AID hits the jackpot when missing the target.Current opinion in immunology · 2016Review
- Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response.Frontiers in immunology · 2015Review
- Old questions, new tools: does next-generation sequencing hold the key to unraveling intestinal B-cell responses?Mucosal immunology · 2015Review
- Article
- Epigenetic control of immunity.Cold Spring Harbor perspectives in biology · 2014Article
- Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.PLoS biology · 2014Article
- The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?Frontiers in immunology · 2014Review
- Genomic Architecture may Influence Recurrent Chromosomal Translocation Frequency in the Igh Locus.Frontiers in immunology · 2013Review
- Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.Immunity · 2013Article
- 4C-ing the Igh Landscape.Immunity · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Immunoglobulin variable region exons are assembled from discontinuous variable (V), diversity (D), and joining (J) segments by the process of V(D)J recombination. V(D)J rearrangements of the immunoglobulin heavy chain (IgH) locus are tightly controlled in a tissue-specific, ordered and allele-specific manner by regulating accessibility of V, D, and J segments to the recombination activating gene proteins which are the specific components of the V(D)J recombinase. In this review we discuss recent advances and established models brought forward to explain the mechanisms underlying accessibility control of V(D)J recombination, including research on germline transcripts, spatial organization, and chromatin modifications of the immunoglobulin heavy chain (IgH) locus. Furthermore, we review the functions of well-described and potential new cis-regulatory elements with regard to processes such as V(D)J recombination, allelic exclusion, and IgH class switch recombination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.