ArticleDigestive diseases and sciences2009
Clinical significance of anti-HEV IgA in diagnosis of acute genotype 4 hepatitis E virus infection negative for anti-HEV IgM.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- ORF2 of hepatitis E virus: genetic and antigenic variation across genotypes and implications for immunity, diagnostics and vaccine development.The Journal of general virology · 2026Review
- Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control.International journal of molecular sciences · 2023Review
- Review
- Calibrating Hepatitis E Virus Serological Assays Using Asymptomatic Specimens Obtained in Japan.Microbiology spectrum · 2022Article
- Diagnostic Value of IgA Antibody Measurement in Tick-Borne Spotted Fever (Astrakhan Rickettsial Fever).Microbiology spectrum · 2022Article
- Hepatitis E virus prevalence among blood donors in Dali, China.Virology journal · 2021Article
- Comprehensive Evaluation of Hepatitis E Serology and Molecular Testing in a Large Cohort.Pathogens (Basel, Switzerland) · 2020Article
- High sensitivity of domestic pigs to intravenous infection with HEV.BMC veterinary research · 2018Article
- Detection of virus-specific polymeric immunoglobulin A in acute hepatitis A, C, E virus serum samples using novel chimeric secretory component.BMC research notes · 2018Article
- Public health risks associated with hepatitis E virus (HEV) as a food-borne pathogen.EFSA journal. European Food Safety Authority · 2017Article
- Performance of Hepatitis E Virus (HEV)-antibody tests: a comparative analysis based on samples from individuals with direct contact to domestic pigs or wild boar in Germany.Medical microbiology and immunology · 2017Article
- Prevalence of hepatitis E virus in slaughter-age pigs in Scotland.Epidemiology and infection · 2015Article
- Seroprevalence of hepatitis E virus (HEV) in humans living in high pig density areas of Germany.Medical microbiology and immunology · 2014Article
- Autochthonous hepatitis e virus infections: a new transfusion-associated risk?Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Review
- Transmission, diagnosis, and management of hepatitis E: an update.Hepatic medicine : evidence and research · 2014Review
- Host immune status and response to hepatitis E virus infection.Clinical microbiology reviews · 2014Review
- Use of immuno-dominant epitope derived from genotype 4 as a diagnostic reagent for detecting the antibodies against Hepatitis E Virus.Virology journal · 2013Article
- Clinical characteristics and risk factors of sporadic Hepatitis E in central China.Virology journal · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anti-HEV IgM is a diagnostic for recent or ongoing HEV infection. However, some patients with acute hepatitis E (AHE) negative for anti-HEV IgM in acute period were often observed in clinical practice. In this study, we constructed the anti-HEV IgA indirect ELISA assay to evaluate the significance of anti-HEV IgA. The specificity of anti-HEV IgA was 99.6%. Among 245 AHE patients, 84 samples from 84 patients were positive for HEV RNA. The positive rate of anti-HEV IgA, anti-HEV IgM and anti-HEV IgG in 84 samples positive for HEV RNA was 96.3, 97.6, and 88.1%, respectively, and no sample was negative for anti-HEV IgA and anti-HEV IgM simultaneously. Among 245 AHE patients, we found nine samples collected from nine patients in acute period were negative for anti-HEV IgM but positive for anti-HEV IgA and two samples were positive for HEV RNA. Detection of anti-HEV IgA can be a useful supplement for diagnosis of acute HEV infection especially in patients negative for anti-HEV IgM.
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