ArticleGenesis (New York, N.Y. : 2000)2009
Inducible site-specific recombination in neural stem/progenitor cells.
Article in Genesis (New York, N.Y. : 2000), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 73 citations in OpenAlex.
- The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis.Stem cell reports · 2025Article
- Glioblastoma functional heterogeneity and enrichment of cancer stem cells with tumor recurrence.Neuron · 2024Article
- Tumor progression is independent of tumor-associated macrophages in cell lineage-based mouse models of glioblastoma.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- LRP4 is required for the olfactory association task in the piriform cortex.Cell & bioscience · 2022Article
- Protocol for sleep analysis in the brain of genetically modified adult mice.STAR protocols · 2021Article
- Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression.Cell stem cell · 2021Article
- High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell Lineage-Based Stratification for Glioblastoma.Cancer cell · 2020Article
- Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression ofeLife · 2020Article
- Nestin-expressing progenitor cells: function, identity and therapeutic implications.Cellular and molecular life sciences : CMLS · 2018Review
- Tuberous sclerosis complex-associated CNS abnormalities depend on hyperactivation of mTORC1 and Akt.The Journal of clinical investigation · 2018Article
- TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response.Nature communications · 2017Article
- Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis.Scientific reports · 2017Article
- Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis.PloS one · 2015Article
- Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms.Frontiers in molecular neuroscience · 2015Review
- Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma.Cancer cell · 2014Article
- NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.Genes & development · 2014Article
- Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting.Journal of neuroscience methods · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To establish a genetic tool for manipulating the neural stem/progenitor cell (NSC) lineage in a temporally controlled manner, we generated a transgenic mouse line carrying an NSC-specific nestin promoter/enhancer expressing a fusion protein encoding Cre recombinase coupled to modified estrogen receptor ligand-binding domain (ER(T2)). In the background of the Cre reporter mouse strain Rosa26(lacZ), we show that the fusion CreER(T2) recombinase is normally silent but can be activated by the estrogen analog tamoxifen both in utero, in infancy, and in adulthood. As assayed by beta-galactosidase activity in embryonic stages, tamoxifen activates Cre recombinase exclusively in neurogenic cells and their progeny. This property persists in adult mice, but Cre activity can also be detected in granule neurons and Bergmann glia at the anterior of the cerebellum, in piriform cortex, optic nerve, and some peripheral ganglia. No obvious Cre activity was observed outside of the nervous system. Thus, the nestin regulated inducible Cre mouse line provides a powerful tool for studying the physiology and lineage of NSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.