ArticleMultiscale modeling & simulation : a SIAM interdisciplinary journal2005
MULTISCALE TWO-DIMENSIONAL MODELING OF A MOTILE SIMPLE-SHAPED CELL.
Article in Multiscale modeling & simulation : a SIAM interdisciplinary journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Nonlinear Stability in a Free Boundary Model of Active Locomotion.Archive for rational mechanics and analysis · 2026Article
- Analysis of the spatio-temporal dynamics of a Rho-GEF-H1-myosin activator-inhibitor reaction-diffusion system.Royal Society open science · 2025Article
- Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism.Molecular biology of the cell · 2023Article
- Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.Biophysical journal · 2020Article
- Simple Rho GTPase Dynamics Generate a Complex Regulatory Landscape Associated with Cell Shape.Biophysical journal · 2020Article
- Thermodynamically consistent treatment of the growth of a biopolymer in the presence of a smooth obstacle interaction potential.Physical review. E · 2019Article
- Correlated random walks inside a cell: actin branching and microtubule dynamics.Journal of mathematical biology · 2019Article
- Modelling actin polymerization: the effect on confined cell migration.Biomechanics and modeling in mechanobiology · 2019Article
- A master equation approach to actin polymerization applied to endocytosis in yeast.PLoS computational biology · 2017Article
- A free-boundary model of a motile cell explains turning behavior.PLoS computational biology · 2017Article
- Mathematical modeling of Myosin induced bistability of Lamellipodial fragments.Journal of mathematical biology · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration.Scientific reports · 2016Article
- On a poroviscoelastic model for cell crawling.Journal of mathematical biology · 2015Article
- A conservative algorithm for parabolic problems in domains with moving boundaries.Journal of computational physics · 2014Article
- A mathematical model of the coupled mechanisms of cell adhesion, contraction and spreading.Journal of mathematical biology · 2014Article
- Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility.Molecular biology of the cell · 2013Article
- Modeling the synergy of cofilin and Arp2/3 in lamellipodial protrusive activity.Biophysical journal · 2013Article
- Periodic migration in a physical model of cells on micropatterns.Physical review letters · 2013Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Cell crawling is an important biological phenomenon underlying coordinated cell movement in morphogenesis, cancer, and wound healing. In recent decades the process of cell crawling has been experimentally and theoretically dissected into further subprocesses: protrusion of the cell at its leading edge, retraction of the cell body, and graded adhesion. A number of one-dimensional (1-D) models explain successfully a proximal-distal organization and movement of the motile cell. However, more adequate two-dimensional (2-D) models are lacking. We propose a multiscale 2-D computational model of the lamellipodium (motile appendage) of a simply shaped, rapidly crawling fish keratocyte cell. We couple submodels of (i) protrusion and adhesion at the leading edge, (ii) the elastic 2-D lamellipodial actin network, (iii) the actin-myosin contractile bundle at the rear edge, and (iv) the convection-reaction-diffusion actin transport on the free boundary lamellipodial domain. We simulate the combined model numerically using a finite element approach. The simulations reproduce observed cell shapes, forces, and movements and explain some experimental results on perturbations of the actin machinery. This novel 2-D model of the crawling cell makes testable predictions and posits questions to be answered by future modeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.