ArticleNature methods2009
Literature-curated protein interaction datasets.
Article in Nature methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis defines principles for the design and analysis of co-fractionation mass spectrometry experiments.Nature methods · 2021Pooled it
- A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation.Nature communications · 2026Article
- Experimental assessment of AI-based interactome mapping.Nature communications · 2026Article
- A beneficial environment promotes immune resilience through epigenetic regulation.Science advances · 2026Article
- Unravelling the human taste receptor interactome: machine learning and molecular modelling insights into protein-protein interactions.NPJ science of food · 2025Article
- Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.Biology methods & protocols · 2024Article
- Network medicine: an approach to complex kidney disease phenotypes.Nature reviews. Nephrology · 2023Review
- Next-generation large-scale binary protein interaction network for Drosophila melanogaster.Nature communications · 2023Article
- High-Throughput Protein-Protein Interactions Screening Using Pool-Based Liquid Yeast Two-Hybrid Pipeline.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Illuminating the dark protein-protein interactome.Cell reports methods · 2022Review
- Autoreactive CD8Nature immunology · 2022Article
- Essential Regression: A generalizable framework for inferring causal latent factors from multi-omic datasets.Patterns (New York, N.Y.) · 2022Article
- Artificial intelligence in cancer target identification and drug discovery.Signal transduction and targeted therapy · 2022Review
- Machine Learning Advances in Microbiology: A Review of Methods and Applications.Frontiers in microbiology · 2022Review
- A network view of human immune system and virus-human interaction.Frontiers in immunology · 2022Article
- Biomedical Literature Mining and Its Components.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Systematic discovery of signaling pathways linking immune activation to schizophrenia.iScience · 2021Article
- Revealing protein-protein interactions at the transcriptome scale by sequencing.Molecular cell · 2021Article
- Network medicine in Cardiovascular Research.Cardiovascular research · 2021Review
- IHP-PING-generating integrated human protein-protein interaction networks on-the-fly.Briefings in bioinformatics · 2021Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.