ArticleThe American journal of clinical nutrition2009
Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokers.
Article in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Vitamin intake and pancreatic cancer risk reduction: A meta-analysis of observational studies.Medicine · 2018Pooled it
- Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies.Medicine · 2016Pooled it
- Vitamin E intake and pancreatic cancer risk: a meta-analysis of observational studies.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Associations Between Intakes of Carotenoids and Tocopherols with Risk of Pancreatic Cancer in a Population-Based Case-Control Study.Journal of the American Nutrition Association · 2025Article
- Exploring the potential of tocopherols: mechanisms of action and perspectives in the prevention and treatment of breast cancer.Medical oncology (Northwood, London, England) · 2024Review
- Article
- Interaction between vitamin E intake and a COMT gene variant on colorectal cancer risk among Korean adults: a case-control study.Epidemiology and health · 2023Article
- Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?Antioxidants (Basel, Switzerland) · 2022Review
- A Prospective Study of Serum Vitamin E and 28-Year Risk of Lung Cancer.Journal of the National Cancer Institute · 2020Article
- Targeting reactive oxygen species in development and progression of pancreatic cancer.Expert review of anticancer therapy · 2017Review
- Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).The American journal of clinical nutrition · 2016Article
- Dietary total antioxidant capacity and pancreatic cancer risk: an Italian case-control study.British journal of cancer · 2016Article
- Tocopherols in cancer: An update.Molecular nutrition & food research · 2016Review
- Pharmacological potential of tocotrienols: a review.Nutrition & metabolism · 2014Review
- Nut consumption and risk of pancreatic cancer in women.British journal of cancer · 2013Article
- Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.Journal of gastrointestinal cancer · 2013Article
- Antioxidant-induced stress.International journal of molecular sciences · 2012Review
- Sequence variants in antioxidant defense and DNA repair genes, dietary antioxidants, and pancreatic cancer risk.International journal of molecular epidemiology and genetics · 2011Article
- Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.International journal of cancer · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEvidence indicates that vitamin E has anticarcinogenic properties for gastrointestinal cancers; however, few studies have examined this with respect to exocrine pancreatic cancer.
objectiveThe objective was to examine whether vitamin E intake and serum alpha-tocopherol concentrations were prospectively associated with exocrine pancreatic cancer.
designWe conducted a cohort analysis of prediagnostic vitamin E intake (4 tocopherols, 4 tocotrienols), serum alpha-tocopherol concentrations, and pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male Finnish smokers aged 50-69 y at baseline. During follow-up from 1985 to 2004 (maximum: 19.4 y; median: 16 y), 318 incident cases were diagnosed among cohort participants with complete serum samples (n = 29,092); 306 cases had complete dietary data (n = 27,111). Cox proportional hazards models adjusted for age, smoking history, history of diabetes mellitus, and/or serum cholesterol were used to calculate hazard ratios (HRs) and 95% CIs.
resultsHigher alpha-tocopherol concentrations were associated with lower pancreatic cancer risk (highest compared with lowest quintile, HR: 0.52; 95% CI: 0.34, 0.80; P for trend = 0.03; continuous HR: 0.91; 95% CI: 0.84, 0.99). Polyunsaturated fat, a putative prooxidant nutrient, modified the association such that the inverse alpha-tocopherol association was most pronounced in subjects with a high polyunsaturated fat intake (ie, >9.9 g/d; highest compared with lowest quintile, HR: 0.38; 95% CI: 0.20, 0.70; P for trend = 0.03; continuous HR: 0.86; 95% CI: 0.75, 0.97; P for interaction = 0.05 and 0.02, respectively). No associations were observed for dietary tocopherols and tocotrienols.
conclusionOur results support the hypothesis that higher alpha-tocopherol concentrations may play a protective role in pancreatic carcinogenesis in male smokers.
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