ArticleMolecular biology of the cell2009
Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Cohesin preservation across mitosis contributes to restart transcription via Cdk9-mediated activation of RNAPol2.Molecular cell · 2026Article
- Cohesin Mutations in Cancer: Emerging Therapeutic Targets.International journal of molecular sciences · 2021Review
- Review
- Article
- Conserved chromosomal functions of RNA interference.Nature reviews. Genetics · 2020Review
- Identification of novel biomarkers for preeclampsia on the basis of differential expression network analysis.Experimental and therapeutic medicine · 2016Article
- Centrosomes in the DNA damage response--the hub outside the centre.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Review
- A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells.PloS one · 2015Article
- Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.The Journal of cell biology · 2014Article
- Sensors at centrosomes reveal determinants of local separase activity.PLoS genetics · 2014Article
- Separate to operate: control of centrosome positioning and separation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies.Biochimica et biophysica acta · 2014Review
- Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.Molecular and cellular biology · 2014Article
- Inhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis.Cell cycle (Georgetown, Tex.) · 2014Article
- Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.Journal of cell science · 2012Article
- Sororin is a master regulator of sister chromatid cohesion and separation.Cell cycle (Georgetown, Tex.) · 2012Review
- Is cohesin required for spindle-pole-body/centrosome cohesion?Communicative & integrative biology · 2012Article
- Cohesin: a critical chromatin organizer in mammalian gene regulation.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011Review
- Cleavage of cohesin rings coordinates the separation of centrioles and chromatids.Nature cell biology · 2011Article
- Haspin: a newly discovered regulator of mitotic chromosome behavior.Chromosoma · 2010Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Cohesin is an essential protein complex required for sister chromatid cohesion. Cohesin associates with chromosomes and establishes sister chromatid cohesion during interphase. During metaphase, a small amount of cohesin remains at the chromosome-pairing domain, mainly at the centromeres, whereas the majority of cohesin resides in the cytoplasm, where its functions remain unclear. We describe the mitosis-specific recruitment of cohesin to the spindle poles through its association with centrosomes and interaction with nuclear mitotic apparatus protein (NuMA). Overexpression of NuMA enhances cohesin accumulation at spindle poles. Although transient cohesin depletion does not lead to visible impairment of normal spindle formation, recovery from nocodazole-induced spindle disruption was significantly impaired. Importantly, selective blocking of cohesin localization to centromeres, which disrupts centromeric sister chromatid cohesion, had no effect on this spindle reassembly process, clearly separating the roles of cohesin at kinetochores and spindle poles. In vitro, chromosome-independent spindle assembly using mitotic extracts was compromised by cohesin depletion, and it was rescued by addition of cohesin that was isolated from mitotic, but not S phase, cells. The combined results identify a novel spindle-associated role for human cohesin during mitosis, in addition to its function at the centromere/kinetochore regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.