ArticleJournal of virology2009
Discovery of a novel single-stranded DNA virus from a sea turtle fibropapilloma by using viral metagenomics.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 140 citations in OpenAlex.
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- First Report on Detection and Complete Genomic Analysis of a Novel CRESS DNA Virus from Sea Turtles.Pathogens (Basel, Switzerland) · 2023Article
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- Emergence of a Novel Pathogenic Poxvirus Infection in the Endangered Green Sea Turtle (Viruses · 2021Article
- Viral Metagenomics Analysis of Rodents From Two Border Provinces Located in Northeast and Southwest China.Frontiers in microbiology · 2021Article
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- Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.Journal of medical virology · 2020Article
- Disease risk analysis in sea turtles: A baseline study to inform conservation efforts.PloS one · 2020Article
- Genetic and functional diversity of double-stranded DNA viruses in a tropical monsoonal estuary, India.Scientific reports · 2018Article
- Teleosts Genomics: Progress and Prospects in Disease Prevention and Control.International journal of molecular sciences · 2018Review
- Limited Correlation of Shotgun Metagenomics Following Host Depletion and Routine Diagnostics for Viruses and Bacteria in Low Concentrated Surrogate and Clinical Samples.Frontiers in cellular and infection microbiology · 2018Article
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- Discovery of fur seal feces-associated circular DNA virus in swine feces in Japan.The Journal of veterinary medical science · 2017Article
- Variation in virome diversity in wild populations ofVirusdisease · 2017Article
- Diverse and highly recombinant anelloviruses associated with Weddell seals in Antarctica.Virus evolution · 2017Article
- Current Advances on Virus Discovery and Diagnostic Role of Viral Metagenomics in Aquatic Organisms.Frontiers in microbiology · 2017Review
- Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral metagenomics, consisting of viral particle purification and shotgun sequencing, is a powerful technique for discovering viruses associated with diseases with no definitive etiology, viruses that share limited homology with known viruses, or viruses that are not culturable. Here we used viral metagenomics to examine viruses associated with sea turtle fibropapillomatosis (FP), a debilitating neoplastic disease affecting sea turtles worldwide. By means of purifying and shotgun sequencing the viral community directly from the fibropapilloma of a Florida green sea turtle, a novel single-stranded DNA virus, sea turtle tornovirus 1 (STTV1), was discovered. The single-stranded, circular genome of STTV1 was approximately 1,800 nucleotides in length. STTV1 has only weak amino acid level identities (25%) to chicken anemia virus in short regions of its genome; hence, STTV1 may represent the first member of a novel virus family. A total of 35 healthy turtles and 27 turtles with FP were tested for STTV1 using PCR, and only 2 turtles severely afflicted with FP were positive. The affected turtles were systemically infected with STTV1, since STTV1 was found in blood and all major organs. STTV1 exists as a quasispecies, with several genome variants identified in the fibropapilloma of each positive turtle, suggesting rapid evolution of this virus. The STTV1 variants were identical over the majority of their genomes but contained a hypervariable region with extensive divergence. This study demonstrates the potential of viral metagenomics for discovering novel viruses directly from animal tissue, which can enhance our understanding of viral evolution and diversity.
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