ArticleJournal of virology2009
Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis.Genome biology · 2026Article
- Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland.Cell communication and signaling : CCS · 2018Article
- Baculovirus PTP2 Functions as a Pro-Apoptotic Protein.Viruses · 2018Article
- Manipulation of apoptosis and necroptosis signaling by herpesviruses.Medical microbiology and immunology · 2015Review
- Review
- HSV-2 specifically down regulates HLA-C expression to render HSV-2-infected DCs susceptible to NK cell killing.PLoS pathogens · 2013Article
- Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T cells.Journal of virology · 2010Article
- Article
- Baculovirus DNA replication-specific expression factors trigger apoptosis and shutoff of host protein synthesis during infection.Journal of virology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Herpes simplex virus (HSV) inhibits apoptosis induced by external stimuli in epithelial cells. In contrast, apoptosis is the primary outcome in HSV-infected lymphocytes. Here, we show that HSV type 2 (HSV-2) gene expression appears to be necessary for the induction of apoptosis in Jurkat cells, a T-cell leukemia line. HSV-2 ICP10 gene expression is sufficient to induce apoptosis in Jurkat cells, while its expression protects epithelial HEp-2 cells from apoptosis triggered by cycloheximide and tumor necrosis factor alpha. Thus, the effect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell type.
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Registered trials
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