ArticleThe Journal of clinical endocrinology and metabolism2009
Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Pooled it
- Pooled it
- Nutrients, Diet, and Other Factors in Prenatal Life and Bone Health in Young Adults: A Systematic Review of Longitudinal Studies.Nutrients · 2020Pooled it
- Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial.The lancet. Diabetes & endocrinology · 2016Trial
- Trial
- Article
- Month-of-Birth Effect on Muscle Mass and Strength in Community-Dwelling Older Women: The French EPIDOS Cohort.Nutrients · 2022Article
- Article
- Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength.Children (Basel, Switzerland) · 2022Article
- The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial.Therapeutic advances in musculoskeletal disease · 2021Review
- Vitamin D, and Maternal and Child Health.Calcified tissue international · 2020Review
- Vitamin D supplementation in pregnancy-a survey of compliance with recommendations.Irish journal of medical science · 2018Article
- Maternal vitamin D supplementation during pregnancy.British medical bulletin · 2018Review
- Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study.Nutrients · 2017Article
- Vitamin D deficiency prevalence and risk factors among pregnant Chinese women.Public health nutrition · 2017Article
- Prenatal exposure to vitamin D from fortified margarine and risk of fractures in late childhood: period and cohort results from 222 000 subjects in the D-tect observational study.The British journal of nutrition · 2017Observational
- Article
- Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: a cross-sectional study.BMC pregnancy and childbirth · 2016Article
- Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.The Journal of clinical endocrinology and metabolism · 2016Review
- ENDOCRINOLOGY IN PREGNANCY: Influence of maternal vitamin D status on obstetric outcomes and the fetal skeleton.European journal of endocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
contextRelationships between vitamin D exposure of the mother in pregnancy and skeletal development of the child are poorly understood.
objectivesOur objectives were to establish whether background UVB levels in the third trimester of pregnancy are related to bone mineral content (BMC) of the child, and to examine whether these relationships are explained by effects on height, fat, or lean mass.
designThis was a prospective cohort study.
settingThe Avon Longitudinal Study of Parents and Children, a population-based birth cohort, was studied.
participantsA total of 6995 boys and girls with a mean age of 9.9 yr was studied. OUTCOME MEASURES: Prespecified analyses of relationships between background UVB levels in the third trimester of pregnancy, and total body less head BMC, bone area (BA), bone mineral density, and area-adjusted BMC as measured by dual-energy x-ray absorptiometry scans at 9.9 yr were performed.
resultsMaternal UVB exposure was positively related to BMC (g) [9.6 (5.3, 13.8)], BA (cm(2)) [8.1 (4.3, 11.9)], and bone mineral density (g/cm(-2)) [0.003 (0.001, 0.004)], but not area-adjusted BMC (g) [0.69 (-0.22, 1.56)], suggesting an effect on bone size. Both height-dependent (cm) [0.18 (0.03, 0.32)] and height-independent (cm(2)) [4.1, (2.0, 6.2)] effects contributed to this association between UVB and BA. Although maternal UVB exposure was also related to lean mass (g) [163 (89, 237)], a positive association between UVB and BA persisted after adjusting for both height and lean mass [2.8 (1.0, 4.6)].
conclusionsMaternal UVB exposure is related to bone size at age 9.9 yr independently of height and lean mass, suggesting that vitamin D status in pregnancy exerts direct effects on periosteal bone formation in subsequent childhood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.