ArticleThe Journal of biological chemistry2009
An alternative form of replication protein a prevents viral replication in vitro.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Replication Protein A, the Main Eukaryotic Single-Stranded DNA Binding Protein, a Focal Point in Cellular DNA Metabolism.International journal of molecular sciences · 2024Review
- Upregulated RPA2 in endometrial tissues of repeated implantation failure patients impairs the endometrial decidualization.Journal of assisted reproduction and genetics · 2023Article
- Article
- Single-Stranded DNA-Binding Proteins in the Archaea.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae.Experimental cell research · 2015Article
- Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.European journal of human genetics : EJHG · 2015Article
- Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians.Critical reviews in biochemistry and molecular biology · 2010Review
- Functions of alternative replication protein A in initiation and elongation.Biochemistry · 2010Article
- Functional characterization of a cancer causing mutation in human replication protein A.Molecular cancer research : MCR · 2010Article
- Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.The Journal of biological chemistry · 2010Article
- An alternative form of replication protein a expressed in normal human tissues supports DNA repair.The Journal of biological chemistry · 2010Article
- A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.Nucleic acids research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Replication protein A (RPA), the eukaryotic single-stranded DNA-binding complex, is essential for multiple processes in cellular DNA metabolism. The "canonical" RPA is composed of three subunits (RPA1, RPA2, and RPA3); however, there is a human homolog to the RPA2 subunit, called RPA4, that can substitute for RPA2 in complex formation. We demonstrate that the resulting "alternative" RPA (aRPA) complex has solution and DNA binding properties indistinguishable from the canonical RPA complex; however, aRPA is unable to support DNA replication and inhibits canonical RPA function. Two regions of RPA4, the putative L34 loop and the C terminus, are responsible for inhibiting SV40 DNA replication. Given that aRPA inhibits canonical RPA function in vitro and is found in nonproliferative tissues, these studies indicate that RPA4 expression may prevent cellular proliferation via replication inhibition while playing a role in maintaining the viability of quiescent cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.