ArticleJournal of neuroscience research2009
Vessel microport technique for applications in cerebrovascular research.
Article in Journal of neuroscience research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 33 citations in OpenAlex.
- Sphingosine 1-Phosphate Signaling Is Involved in Impaired Blood-Brain Barrier Function in Ischemia-Reperfusion Injury.Molecular neurobiology · 2020Article
- Maintaining unperturbed cerebral blood flow is key in the study of brain metastasis and its interactions with stress and inflammatory responses.Brain, behavior, and immunity · 2017Article
- Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology.Molecular and cellular neurosciences · 2017Article
- Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area.Journal of visualized experiments : JoVE · 2017Article
- Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery.Journal of visualized experiments : JoVE · 2017Article
- Dietary Selenium Supplementation Modulates Growth of Brain Metastatic Tumors and Changes the Expression of Adhesion Molecules in Brain Microvessels.Biological trace element research · 2016Article
- Exercise maintains blood-brain barrier integrity during early stages of brain metastasis formation.Biochemical and biophysical research communications · 2015Article
- Selective intra-arterial drug administration in a model of large vessel ischemia.Journal of neuroscience methods · 2015Article
- Minimally Invasive Monitoring of Chronic Central Venous Catheter Patency in Mice Using Digital Subtraction Angiography (DSA).PloS one · 2015Article
- Intra-arterial delivery of AAV vectors to the mouse brain after mannitol mediated blood brain barrier disruption.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- PPAR agonist-mediated protection against HIV Tat-induced cerebrovascular toxicity is enhanced in MMP-9-deficient mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.PloS one · 2014Article
- Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood-brain barrier.Molecular neurodegeneration · 2013Article
- Autophagy is involved in nanoalumina-induced cerebrovascular toxicity.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- A Low Cost Metal-Free Vascular Access Mini-Port for Artifact Free Imaging and Repeated Injections in Mice.PloS one · 2013Article
- TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles.PloS one · 2013Article
- Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling.Toxicology · 2012Article
- Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits.Neurobiology of aging · 2012Article
- Rodent models of HAND and drug abuse: exogenous administration of viral protein(s) and cocaine.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cerebrovascular research suffers from a lack of reliable methods with which to deliver exogenous substances effectively into the central nervous system (CNS) of small experimental animals. Here we describe a novel vessel microport surgical technique for a variety of cerebrovascular applications that is reproducible and well tolerated in mice. The procedure is based on the insertion of a vessel microport into the external carotid artery for substance delivery into the CNS via the internal carotid artery. The method results in selective substance delivery into the ipsilateral hemisphere. Other novel aspects of this surgical technique include the ability to perform multiple injections, study of conscious mice well removed from surgery, and lack of occlusion of the common or internal carotid artery that allows carotid flow to be maintained. The feasibility of this technique has been validated by infusion of HIV Tat protein to induce permeability of the blood-brain barrier and by implantation of tumor cells to establish a brain metastasis model. Thus, the described vessel microport technique can be employed in a variety of cerebrovascular research applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.