Evidence map›Paper›PMID 19115131›Full record

ArticleJournal of neurovirology2009

Theiler's murine encephalomyelitis virus attachment to the gastrointestinal tract is associated with sialic acid binding.

Ikuo Tsunoda, Jane E Libbey, Robert S Fujinami

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurovirology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Clinical & experimental neuroimmunology · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ikuo TsunodaDepartment of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.
Jane E Libbey
Robert S Fujinami
University of Utah · US

Funding

VIRAL AND CELLULAR DETERMINANTS INVOLVED IN CNS DISEASER01NS034497 · NINDS · UNIVERSITY OF UTAH · PI FUJINAMI, ROBERT S · 1995 to 2004
$1.0M
Axonal degeneration can trigger demyelinating diseaseR21NS059724 · NINDS · UNIVERSITY OF UTAH · PI TSUNODA, IKUO · 2008 to 2009
$357k
NINDS NIH HHS R01 NS 034497NINDS NIH HHS R01 NS034497NINDS NIH HHS R21 NS059724
6 · The paper itself

Abstract

DA and GDVII are strains of Theiler's murine encephalomyelitis virus (TMEV). DA virus mutant DApB encodes VP2 puff B of GDVII, whereas DApBL2M contains VP1 loop II of GDVII with a point mutation in VP2 puff B. Neuraminidase treatment of cells inhibited infection by DA and DApB, but not GDVII or DApBL2M viruses; sialic acid (SA) binding correlated with virus persistence. In virus binding assays to intestine sections, all four TMEVs bound goblet cells and the mucus of the epithelium that was SA dependent. Therefore, differences in SA composition on different cell types can affect tropism and infection.

Indexed as

Virus AttachmentAnimalsCardiovirus InfectionsCell LineCricetinaeIntestinal MucosaMiceMutationN-Acetylneuraminic AcidTheilovirusN-Acetylneuraminic Acid

Identifiers

PMID19115131
PMCPMC2882804
OpenAlexW2160141952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.