ArticleInternational urology and nephrology2009
Creatinine reabsorption by the aged kidney.
Article in International urology and nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
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- Dialysis for older adults: why should the targets be different?Journal of nephrology · 2024Review
- Development of a Longitudinal Diagnosis and Prognosis in Patients with Chronic Kidney Disease: Intelligent Clinical Decision-Making Scheme.International journal of environmental research and public health · 2021Article
- Molecular nephrology: types of acute tubular injury.Nature reviews. Nephrology · 2019Review
- Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics.Seminars in nephrology · 2018Review
- Tubular secretion in chronic kidney disease staging: a new proposal.International urology and nephrology · 2017Article
- Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.Journal of the American Society of Nephrology : JASN · 2016Article
- A New Method for Individualized Digoxin Dosing in Elderly Patients.Drugs & aging · 2016Article
- Clinical impact of indirect markers of renal function in elderly patients with hip fracture.Geriatric orthopaedic surgery & rehabilitation · 2014Article
- Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old.World journal of nephrology · 2012Article
- Renal creatinine handling in very old patients with chronic renal disease.International urology and nephrology · 2011Article
- Renal reserve in the oldest old.International urology and nephrology · 2011Article
- Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions.Expert opinion on drug metabolism & toxicology · 2011Review
- Acute kidney injury in the elderly population.International urology and nephrology · 2010Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe handling of renal creatinine in human beings has classically been described as the result of two particular physiological processes: glomerular filtration and proximal tubular secretion. However, there are particular physiological situations in which tubular creatinine reabsorption has been documented, such as in the case of healthy newborns and premature babies. We performed a prospective study in order to evaluate if there is tubular creatinine reabsorption in healthy elderly people. PATIENTS AND
methodWe studied prospectively nine healthy volunteers, four of them young (20-33 years old) and the remaining five, old (65-73 years old). Since creatinine is secreted in the proximal tubules, and its secretion can be completely blocked by cimetidine administration, a creatinine clearance with cimetidine reliably represents the glomerular filtration rate. Therefore, if the ratio creatinine clearance (Ccr)/creatinine clearance with cimetidine (CcrWC) is higher than one, this would indicate net creatinine secretion, whereas a ratio lower than one would indicate a net renal creatinine tubular reabsorption; a ratio equal to one indicates creatinine filtration. Finally, the Ccr, CcrWC, and Ccr/CcrWC ratios were compared between the young and old group. STATISTICAL TESTS: Mann-Whitney and Wilcoxon tests were used.
resultsAs expected, creatinine clearance in the elderly was significantly lower than in the young [Ccr: 74.4 ml/min (47.9-100.9) (old) vs. 153.8 ml/min (108.3-199.2) (young), p = 0.014]. Similarly, the creatinine clearance with cimetidine (CcrWC) was significantly lower in the elderly compared to the young [CcrWC: 81.8 ml/min (69.2-94.5) (old) vs. 122.5 ml/min (82.6-162.4) (young), p = 0.028]. The ratio of Ccr/CcrWC was 0.9 in the elderly vs. 1.26 in the young (p = 0.014), indicating net creatinine reabsorption in the elderly and net creatinine secretion in the young.
conclusionOur findings indicate that there seems to be a net reabsorption of creatinine in the renal tubules of healthy old persons.
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