ArticlePlant molecular biology2009
The Arabidopsis DNA mismatch repair gene PMS1 restricts somatic recombination between homeologous sequences.
Article in Plant molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic dissection of MutL complexes in Arabidopsis meiosis.Nucleic acids research · 2025Article
- A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate.Plant physiology · 2022Article
- Comparative phylogenomic analyses and co-expression gene network reveal insights in flowering time and aborted meiosis in woody bamboo,Frontiers in plant science · 2022Article
- Effects ofFrontiers in plant science · 2020Article
- Structural Aspects of DNA Repair and Recombination in Crop Improvement.Frontiers in genetics · 2020Review
- New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization.Frontiers in plant science · 2019Article
- Identification of candidate genes associated with fertility restoration of cytoplasmic male-sterility in onion (Allium cepa L.) using a combination of bulked segregant analysis and RNA-seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Yeast mutator phenotype enforced by Arabidopsis PMS1 expression.Molecular biology reports · 2013Article
- Research on plants for the understanding of diseases of nuclear and mitochondrial origin.Journal of biomedicine & biotechnology · 2012Review
- Effects of suppressing the DNA mismatch repair system on homeologous recombination in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- High-level production of MSH2 from Arabidopsis thaliana: a DNA mismatch repair system key subunit.Molecular biotechnology · 2011Article
- PMS1 from Arabidopsis thaliana: optimization of protein overexpression in Escherichia coli.Molecular biology reports · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eukaryotic DNA mismatch repair (MMR) system contributes to maintaining the fidelity of genetic information by correcting replication errors and preventing illegitimate recombination events. This study aimed to examine the function(s) of the Arabidopsis thaliana PMS1 gene (AtPMS1), one of three homologs of the bacterial MutL gene in plants. Two independent mutant alleles (Atpms1-1 and Atpms1-2) were obtained and one of these (Atpms1-1) was studied in detail. The mutant exhibited a reduction in seed set and a bias against the transmission of the mutant allele. Somatic recombination, both homologous and homeologous, was examined using a set of reporter constructs. Homologous recombination remained unchanged in the mutant while homeologous recombination was between 1.7- and 4.8-fold higher than in the wild type. This increase in homeologous recombination frequency was not correlated with the degree of sequence divergence. In RNAi lines, a range of increases in homeologous recombination were observed with two lines showing a 3.3-fold and a 3.6-fold increase. These results indicate that the AtPMS1 gene contributes to an antirecombination activity aimed at restricting recombination between diverged sequences.
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