ArticleProceedings of the National Academy of Sciences of the United States of America2009
Force generation by a dynamic Z-ring in Escherichia coli cell division.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 85 citations in OpenAlex.
- Energy allocation theory for bacterial growth control in and out of steady state.bioRxiv : the preprint server for biology · 2024Article
- A novel amphiphilic motif at the C-terminus of FtsZ1 facilitates chloroplast division.The Plant cell · 2022Article
- Membrane rigidity regulates E. coli proliferation rates.Scientific reports · 2022Article
- Computational modeling of unphosphorylated CtrA:iScience · 2021Article
- Targeting the Achilles Heel of FtsZ: The Interdomain Cleft.Frontiers in microbiology · 2021Review
- The Assembly Switch Mechanism of FtsZ Filament Revealed by All-Atom Molecular Dynamics Simulations and Coarse-Grained Models.Frontiers in microbiology · 2021Article
- The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature.PloS one · 2020Article
- Beyond force generation: Why is a dynamic ring of FtsZ polymers essential for bacterial cytokinesis?BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Z-ring Structure and Constriction Dynamics inFrontiers in microbiology · 2017Article
- Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.Bioorganic & medicinal chemistry · 2016Review
- Redefining the roles of the FtsZ-ring in bacterial cytokinesis.Current opinion in microbiology · 2016Review
- Targeting the Bacterial Division Protein FtsZ.Journal of medicinal chemistry · 2016Review
- Defining the rate-limiting processes of bacterial cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Phase-field modelling of the dynamics of Z-ring formation in liposomes: Onset of constriction and coarsening.The European physical journal. E, Soft matter · 2015Article
- Bacterial actin and tubulin homologs in cell growth and division.Current biology : CB · 2015Review
- Bacterial cell division: experimental and theoretical approaches to the divisome.Science progress · 2015Review
- An intrinsically disordered linker plays a critical role in bacterial cell division.Seminars in cell & developmental biology · 2015Review
- Site-directed fluorescence labeling reveals a revised N-terminal membrane topology and functional periplasmic residues in the Escherichia coli cell division protein FtsK.The Journal of biological chemistry · 2014Article
- Article
- Cell shape can mediate the spatial organization of the bacterial cytoskeleton.Biophysical journal · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FtsZ, a bacterial homologue of tubulin, plays a central role in bacterial cell division. It is the first of many proteins recruited to the division site to form the Z-ring, a dynamic structure that recycles on the time scale of seconds and is required for division to proceed. FtsZ has been recently shown to form rings inside tubular liposomes and to constrict the liposome membrane without the presence of other proteins, particularly molecular motors that appear to be absent from the bacterial proteome. Here, we propose a mathematical model for the dynamic turnover of the Z-ring and for its ability to generate a constriction force. Force generation is assumed to derive from GTP hydrolysis, which is known to induce curvature in FtsZ filaments. We find that this transition to a curved state is capable of generating a sufficient force to drive cell-wall invagination in vivo and can also explain the constriction seen in the in vitro liposome experiments. Our observations resolve the question of how FtsZ might accomplish cell division despite the highly dynamic nature of the Z-ring and the lack of molecular motors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.