ArticleThe Journal of cell biology2008
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed, 74 citations in OpenAlex.
- Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure.Frontiers in cell and developmental biology · 2025Article
- Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.Nature biomedical engineering · 2023Article
- Induction ofJournal of clinical biochemistry and nutrition · 2023Article
- ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors.Nature communications · 2023Article
- Article
- Proliferation rate and differentiation potential are independent during the transition from neurogenesis to gliogenesis in the mouse embryonic spinal cord.IBRO neuroscience reports · 2021Article
- Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence.Development (Cambridge, England) · 2020Article
- Mediator complex interaction partners organize the transcriptional network that defines neural stem cells.Nature communications · 2019Article
- Divide or Commit - Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis.Frontiers in cell and developmental biology · 2019Review
- p53 Mutant p53International journal of biological sciences · 2019Article
- Targeting the T-Lak cell originated protein kinase by OTS964 shrinks the size of power-law coded heterogeneous glioma stem cell populations.Oncotarget · 2018Article
- Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development.Frontiers in molecular neuroscience · 2017Article
- IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.Scientific reports · 2016Article
- Gene Expression Profile of NF-κB, Nrf2, Glycolytic, and p53 Pathways During the SH-SY5Y Neuronal Differentiation Mediated by Retinoic Acid.Molecular neurobiology · 2016Article
- Regulation of the p19(Arf)/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice.Aging cell · 2015Article
- Imprinted Zac1 in neural stem cells.World journal of stem cells · 2015Review
- Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations.PloS one · 2015Article
- Defining the role of oxygen tension in human neural progenitor fate.Stem cell reports · 2014Article
- MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division.EMBO reports · 2014Article
- p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1.Stem cells and development · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modes of proliferation and differentiation of neural stem cells (NSCs) are coordinately controlled during development, but the underlying mechanisms remain largely unknown. In this study, we show that the protooncoprotein Myc and the tumor suppressor p19(ARF) regulate both NSC self-renewal and their neuronal and glial fate in a developmental stage-dependent manner. Early-stage NSCs have low p19(ARF) expression and retain a high self-renewal and neurogenic capacity, whereas late-stage NSCs with higher p19(ARF) expression possess a lower self-renewal capacity and predominantly generate glia. Overexpression of Myc or inactivation of p19(ARF) reverts the properties of late-stage NSCs to those of early-stage cells. Conversely, inactivation of Myc or forced p19(ARF) expression attenuates self-renewal and induces precocious gliogenesis through modulation of the responsiveness to gliogenic signals. These actions of p19(ARF) in NSCs are mainly mediated by p53. We propose that opposing actions of Myc and the p19(ARF)-p53 pathway have important functions in coordinated developmental control of self-renewal and cell fate choices in NSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.