ArticleMolecular and cellular biology2009
The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Emerging role ofFrontiers in molecular neuroscience · 2026Article
- Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5.Epigenetics & chromatin · 2025Article
- The histone demethylase Kdm5 controls Hid-induced cell death inFrontiers in cell death · 2024Article
- Pharmacophore-based virtual screening of ZINC database, molecular modeling and designing new derivatives as potential HDAC6 inhibitors.Molecular diversity · 2023Article
- KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic.Advances in experimental medicine and biology · 2023Article
- Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes-Jensen syndrome.The FEBS journal · 2022Review
- The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis.Nucleic acids research · 2022Article
- Review
- Functions and Interactions of Mammalian KDM5 Demethylases.Frontiers in genetics · 2022Review
- Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma.Blood cancer discovery · 2021Article
- Article
- The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition.PLoS genetics · 2020Article
- The histone demethylase KDM5 controls developmental timing inDevelopment (Cambridge, England) · 2019Article
- Little imaginal discs, a Trithorax group member, is a constituent of nuclear matrix ofJournal of biosciences · 2018Article
- A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.Cell reports · 2018Article
- Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.Nature communications · 2017Article
- JARID1 Histone Demethylases: Emerging Targets in Cancer.Trends in cancer · 2017Review
- The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation.Nucleic acids research · 2017Article
- Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling.Nature communications · 2016Article
- Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity.PLoS genetics · 2016Article
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5 authors.
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Abstract
JmjC domain-containing proteins have been shown to possess histone demethylase activity. One of these proteins is the Drosophila histone H3 lysine 4 demethylase Little imaginal discs (Lid), which has been genetically classified as a Trithorax group protein. However, contrary to the supposed function of Lid in gene activation, the biochemical activity of this protein entails the removal of a histone mark that is correlated with active transcription. To understand the molecular mechanism behind the function of Lid, we have purified a Lid-containing protein complex from Drosophila embryo nuclear extracts. In addition to Lid, the complex contains Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15. Rpd3 is a histone deacetylase, and along with Polycomb group proteins, which antagonize the function of Trithorax group proteins, it negatively regulates transcription. By reconstituting the Lid complex, we demonstrated that the demethylase activity of Lid is not affected by its association with other proteins. However, the deacetylase activity of Rpd3 is greatly diminished upon incorporation into the Lid complex. Thus, our finding that Lid antagonizes Rpd3 function provides an explanation for the genetic classification of Lid as a positive transcription regulator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.