ArticleJournal of bacteriology2009
Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- LeveragingFrontiers in microbiology · 2021Review
- Biosynthesis and Antimicrobial Activity of Pseudodesmin and Viscosinamide Cyclic Lipopeptides Produced by Pseudomonads Associated with the Cocoyam Rhizosphere.Microorganisms · 2020Article
- Biochemistry, genetics and biotechnology of glycerol utilization in Pseudomonas species.Microbial biotechnology · 2020Review
- Antagonism of Two Plant-Growth Promoting Bacillus velezensis Isolates Against Ralstonia solanacearum and Fusarium oxysporum.Scientific reports · 2018Article
- Dynamics of Aspen Roots Colonization by Pseudomonads Reveals Strain-Specific and Mycorrhizal-Specific Patterns of Biofilm Formation.Frontiers in microbiology · 2018Article
- The LuxR Regulators PcoR and RfiA Co-regulate Antimicrobial Peptide and Alginate Production inFrontiers in microbiology · 2018Article
- Biosynthesis of the antimicrobial cyclic lipopeptides nunamycin and nunapeptin by Pseudomonas fluorescens strain In5 is regulated by the LuxR-type transcriptional regulator NunF.MicrobiologyOpen · 2017Article
- Coregulation of the cyclic lipopeptides orfamide and sessilin in the biocontrol strain Pseudomonas sp. CMR12a.MicrobiologyOpen · 2017Article
- AnFrontiers in microbiology · 2017Article
- Exploring the genomic traits of fungus-feeding bacterial genus Collimonas.BMC genomics · 2015Article
- Molecular and chemical dialogues in bacteria-protozoa interactions.Scientific reports · 2015Article
- Continuous enhancement of iturin A production by Bacillus subtilis with a stepwise two-stage glucose feeding strategy.BMC biotechnology · 2015Article
- Article
- The Rsm regulon of plant growth-promoting Pseudomonas fluorescens SS101: role of small RNAs in regulation of lipopeptide biosynthesis.Microbial biotechnology · 2015Article
- Lipopeptide biosynthesis in Pseudomonas fluorescens is regulated by the protease complex ClpAP.BMC microbiology · 2015Article
- Dissection of the cis-2-decenoic acid signaling network in Pseudomonas aeruginosa using microarray technique.Frontiers in microbiology · 2015Article
- Diversity and Activity of Lysobacter Species from Disease Suppressive Soils.Frontiers in microbiology · 2015Article
- Microbial Small Talk: Volatiles in Fungal-Bacterial Interactions.Frontiers in microbiology · 2015Article
- Mangotoxin production of Pseudomonas syringae pv. syringae is regulated by MgoA.BMC microbiology · 2014Article
- Recruitment and rearrangement of three different genetic determinants into a conjugative plasmid increase copper resistance in Pseudomonas syringae.Applied and environmental microbiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic regulatory network. This study provides, for the first time, evidence that the serine protease ClpP regulates the biosynthesis of massetolides, cyclic lipopeptides involved in swarming motility, biofilm formation, and antimicrobial activity of Pseudomonas fluorescens SS101. The results show that ClpP affects the expression of luxR(mA), the transcriptional regulator of the massetolide biosynthesis genes massABC, thereby regulating biofilm formation and swarming motility of P. fluorescens SS101. Transcription of luxR(mA) was significantly repressed in the clpP mutant, and introduction of luxR(mA) restored, in part, massetolide biosynthesis and swarming motility of the clpP mutant. Site-directed mutagenesis and expression analyses indicated that the chaperone subunit ClpX and the Lon protease are not involved in regulation of massetolide biosynthesis and are transcribed independently of clpP. Addition of Casamino Acids enhanced the transcription of luxR(mA) and massABC in the clpP mutant, leading to a partial rescue of massetolide production and swarming motility. The results further suggested that, at the transcriptional level, ClpP-mediated regulation of massetolide biosynthesis operates independently of regulation by the GacA/GacS two-component system. The role of amino acid metabolism and the putative mechanisms underlying ClpP-mediated regulation of cyclic lipopeptide biosynthesis, swarming motility, and growth in P. fluorescens are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.