ArticleGenetics2009
Molecular spectrum of spontaneous de novo mutations in male and female germline cells of Drosophila melanogaster.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic breakdown of a Tet-off conditional lethality system for insect population control.Nature communications · 2020Article
- Synaptonemal Complex-DeficientG3 (Bethesda, Md.) · 2020Article
- Article
- Copy-number changes in evolution: rates, fitness effects and adaptive significance.Frontiers in genetics · 2013Review
- The evolution of genetic architectures underlying quantitative traits.Proceedings. Biological sciences · 2013Article
- High spontaneous rate of gene duplication in Caenorhabditis elegans.Current biology : CB · 2011Article
- A genome-wide view of Caenorhabditis elegans base-substitution mutation processes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We carried out mutation screen experiments to understand the rate and molecular nature of spontaneous de novo mutations in Drosophila melanogaster, which are crucial for many evolutionary issues, but still poorly understood. We screened for eye-color and body-color mutations that occurred in the germline cells of the first generation offspring of wild-caught females. The offspring were from matings that had occurred in the field and therefore had a genetic composition close to that of flies in natural populations. We employed 1554 F(1) individuals from 374 wild-caught females for the experiments to avoid biased contributions of any particular genotype. From approximately 8.6 million alleles screened, we obtained 10 independent mutants: two point mutations (one for each sex), a single deletion of approximately 6 kb in a male, a single transposable element insertion in a female, five large deletions ranging in size from 40 to 500 kb in females, and a single mutation of unknown nature in a male. The five large deletions were presumably generated by nonallelic homologous recombination (NAHR) between transposable elements at different locations, illustrating the mutagenic nature of recombination. The high occurrence of NAHR that we observed has important consequences for genome evolution through the production of segmental duplications.
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Registered trials
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