ArticleBMC microbiology2008
DNA-microarrays identification of Streptococcus mutans genes associated with biofilm thickness.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- A Scorecard for Information Synthesis in Multiple Experimental Conditions: Application to Bacterial Biofilm Matrix Transcriptomics.Current microbiology · 2025Article
- Review
- The Contribution of Photodynamic Inactivation vs. Corsodyl Mouthwash to the Control of Streptococcus mutans Biofilms.Current microbiology · 2020Article
- Khat Chewing Induces a Floral Shift in Dental Material-Associated Microbiota: A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Environmental Triggers ofFrontiers in microbiology · 2020Article
- Inhibitory Effects of Ethyl Gallate onMolecules (Basel, Switzerland) · 2019Article
- Regulation of cid and lrg expression by CcpA in Streptococcus mutans.Microbiology (Reading, England) · 2019Article
- Comparative gene expression analysis of Porphyromonas gingivalis ATCC 33277 in planktonic and biofilms states.PloS one · 2017Article
- Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase.Scientific reports · 2015Article
- Metabolic activity of Streptococcus mutans biofilms and gene expression during exposure to xylitol and sucrose.International journal of oral science · 2014Article
- Hyperosmotic response of streptococcus mutans: from microscopic physiology to transcriptomic profile.BMC microbiology · 2013Article
- Effect of periodontal pathogens on the metatranscriptome of a healthy multispecies biofilm model.Journal of bacteriology · 2012Article
- A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms.Antimicrobial agents and chemotherapy · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA biofilm is a complex community of microorganisms that develop on surfaces in diverse environments. The thickness of the biofilm plays a crucial role in the physiology of the immobilized bacteria. The most cariogenic bacteria, mutans streptococci, are common inhabitants of a dental biofilm community. In this study, DNA-microarray analysis was used to identify differentially expressed genes associated with the thickness of S. mutans biofilms.
resultsComparative transcriptome analyses indicated that expression of 29 genes was differentially altered in 400- vs. 100-microns depth and 39 genes in 200- vs. 100-microns biofilms. Only 10 S. mutans genes showed differential expression in both 400- vs. 100-microns and 200- vs. 100-microns biofilms. All of these genes were upregulated. As sucrose is a predominant factor in oral biofilm development, its influence was evaluated on selected genes expression in the various depths of biofilms. The presence of sucrose did not noticeably change the regulation of these genes in 400- vs. 100-microns and/or 200- vs. 100-microns biofilms tested by real-time RT-PCR. Furthermore, we analyzed the expression profile of selected biofilm thickness associated genes in the luxS- mutant strain. The expression of those genes was not radically changed in the mutant strain compared to wild-type bacteria in planktonic condition. Only slight downregulation was recorded in SMU.2146c, SMU.574, SMU.609, and SMU.987 genes expression in luxS- bacteria in biofilm vs. planktonic environments.
conclusionThese findings reveal genes associated with the thickness of biofilms of S. mutans. Expression of these genes is apparently not regulated directly by luxS and is not necessarily influenced by the presence of sucrose in the growth media.
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