ArticleClinical & experimental metastasis2009
Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells.
Article in Clinical & experimental metastasis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Leptin-induced signaling pathways in cancer cell migration and invasion.Cellular oncology (Dordrecht, Netherlands) · 2019Review
- The potential role of leptin in tumor invasion and metastasis.Cytokine & growth factor reviews · 2017Review
- Targeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis.Oncogene · 2015Article
- Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production.Oncotarget · 2015Article
- Association of serum soluble leptin receptor and leptin levels with breast cancer.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Multifaceted leptin network: the molecular connection between obesity and breast cancer.Journal of mammary gland biology and neoplasia · 2013Review
- Control of body weight versus tumorigenesis by concerted action of leptin and estrogen.Reviews in endocrine & metabolic disorders · 2013Review
- Adipocytes: impact on tumor growth and potential sites for therapeutic intervention.Pharmacology & therapeutics · 2013Review
- JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1.BMC cancer · 2013Article
- Adipokine leptin in obesity-related pathology of breast cancer.Journal of biosciences · 2012Review
- Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.The Journal of biological chemistry · 2012Article
- NFAT promotes carcinoma invasive migration through glypican-6.The Biochemical journal · 2011Article
- Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.Journal of breast cancer · 2011Article
- Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.Carcinogenesis · 2011Article
- Leptin in human physiology and therapeutics.Frontiers in neuroendocrinology · 2010Review
- Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer.Breast cancer research : BCR · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion. However, whether leptin could augment breast cancer cell invasion is not known. Here we showed that leptin increased the invasiveness and the matrix metallo-proteinase-2 (MMP-2) activity of the MCF-7 breast cancer cell line. Leptin stimulated the phosphorylation of extracellular signals regulated kinases, signal transducers and activators of transcription 3 and Jun N-terminal kinases (JNK); however, only inhibition of JNK decreased leptin-mediated activation of MMP-2. Furthermore, inhibition of JNK suppressed leptin-mediated breast cancer cell invasion. Here we report the novel findings that leptin increased invasion of breast cancer cells by activating JNK, resulting in increased MMP-2 activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.