ArticlePloS one2008
Asthma is inversely associated with Helicobacter pylori status in an urban population.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 4 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- The association between Helicobacter pylori infection and asthma risk: an updated systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Helicobacter pylori infection and atopic diseases: is there a relationship? A systematic review and meta-analysis.World journal of gastroenterology · 2014Pooled it
- Is Helicobacter pylori infection associated with asthma risk? A meta-analysis based on 770 cases and 785 controls.International journal of medical sciences · 2012Pooled it
- Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature.Inflammatory bowel diseases · 2010Pooled it
- Helicobacter pylori seropositivity and risk of lung cancer.PloS one · 2012Trial
- The effects of Helicobacter pylori eradication and development of immune-mediated disorder in children: a nationwide population-based study in Korea.The Korean journal of internal medicine · 2026Article
- Neonatal infection withInfection and immunity · 2025Article
- Helicobacter pylori infection is associated with an increased risk of chronic obstructive pulmonary disease and asthma.Gut pathogens · 2025Article
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- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Neutrophil-activating protein inFrontiers in immunology · 2024Article
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- Treatment withFrontiers in immunology · 2023Article
- Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms.International journal of environmental research and public health · 2022Article
- Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis.Frontiers in pharmacology · 2022Review
- The Efficacy of Cancer Immunotherapies Is Compromised byFrontiers in immunology · 2022Review
- Helicobacter pylori infection causes both protective and deleterious effects in human health and disease.Genes and immunity · 2021Review
- The Development of a WTC Environmental Health Center Pan-Cancer Database.International journal of environmental research and public health · 2021Article
- Dendritic cell-derived TGF-β mediates the induction of mucosal regulatory T-cell response to Helicobacter infection essential for maintenance of immune tolerance in mice.Helicobacter · 2020Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMicrobial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma.
methodsAdults were recruited to participate in the New York University (NYU)/Bellevue Asthma Registry in New York City. Adult asthma cases (N = 318) and controls (N = 208) were identified and serum IgG antibodies to H. pylori whole cell antigens or the immunodominant CagA antigen were measured.
resultsAs expected, the asthma cases and controls differed with respect to atopy and lung function. Seropositivity to H. pylori or CagA antigen was present in 47.1% of the total case and control study population. Asthma was inversely associated with CagA seropositivity (OR = 0.57, 95% CI = 0.36-0.89). Median age of onset of asthma (doctor's diagnosis) was older (21 years) among individuals with CagA+ strains than among H. pylori- individuals (11 years) (p = 0.006).
conclusionThese data are consistent with the hypothesis that colonization with CagA+ H. pylori strains is inversely associated with asthma and is associated with an older age of asthma onset in an urban population. The data suggest H. pylori as a marker for protection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.