Cohort studies and the genetics of complex disease.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.Arteriosclerosis, thrombosis, and vascular biology · 2009
   Pooled it
2. The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop.Genetics in medicine : official journal of the American College of Medical Genetics · 2009
   Guideline
3. Dissecting Complex Traits Using Omics Data: A Review on the Linear Mixed Models and Their Application in GWAS.Plants (Basel, Switzerland) · 2022
   Review
4. Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling.Advances in experimental medicine and biology · 2021
   Article
5. Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.PLoS genetics · 2018
   Article
6. Study Design Considerations for Cancer Biomarker Discoveries.The journal of applied laboratory medicine · 2018
   Article
7. The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.Human genetics · 2018
   Article
8. Population-Wide Genetic Risk Prediction of Complex Diseases: A Pilot Feasibility Study in Macau Population for Precision Public Healthcare Planning.Scientific reports · 2018
   Article
9. Recontacting participants for expanded uses of existing samples and data: a case study.Genetics in medicine : official journal of the American College of Medical Genetics · 2017
   Article
10. Search Datasets in Literature: A Case Study of GWAS.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2017
    Article
11. Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes.PloS one · 2017
    Article
12. Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic/Latino Adults Living in Costa Rica.Journal of the American Heart Association · 2016
    Article
13. Cichlid fishes as a model to understand normal and clinical craniofacial variation.Developmental biology · 2016
    Article
14. PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population.Scientific reports · 2016
    Article
15. Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia.Nature communications · 2016
    Article
16. Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy.PloS one · 2016
    Article
17. Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.PLoS genetics · 2015
    Article
18. Burden of disease variants in participants of the Long Life Family Study.Aging · 2015
    Article
19. Unravelling genes and pathways implicated in working memory of schizophrenia in Han Chinese.International journal of molecular sciences · 2015
    Article
20. GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes.Nucleic acids research · 2015
    Article

Corrections and comments

• Comment on
  Common variants at 30 loci contribute to polygenic dyslipidemia.2009
• Comment on
  Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.2009
• Comment on
  Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.2009

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as