ArticleJournal of the American Society for Mass Spectrometry2009
Electron capture and transfer dissociation: Peptide structure analysis at different ion internal energy levels.
Article in Journal of the American Society for Mass Spectrometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Evaluation of Sibling and Twin Fragment Ions Improves the Structural Characterization of Proteins by Top-Down MALDI In-Source Decay Mass Spectrometry.Analytical chemistry · 2020Article
- Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.Mass spectrometry reviews · 2018Review
- Sulfur Pentafluoride is a Preferred Reagent Cation for Negative Electron Transfer Dissociation.Journal of the American Society for Mass Spectrometry · 2017Article
- It is time for top-down venomics.The journal of venomous animals and toxins including tropical diseases · 2017Review
- Structural identification of electron transfer dissociation products in mass spectrometry using infrared ion spectroscopy.Nature communications · 2016Article
- Activated Ion Electron Transfer Dissociation for Improved Fragmentation of Intact Proteins.Analytical chemistry · 2015Article
- Coupling capillary zone electrophoresis with electron transfer dissociation and activated ion electron transfer dissociation for top-down proteomics.Analytical chemistry · 2015Article
- Activated ion ETD performed in a modified collision cell on a hybrid QLT-Oribtrap mass spectrometer.Journal of the American Society for Mass Spectrometry · 2013Article
- Coordination sphere tuning of the electron transfer dissociation behavior of Cu(II)-peptide complexes.Journal of the American Society for Mass Spectrometry · 2012Article
- Activated-ion electron transfer dissociation improves the ability of electron transfer dissociation to identify peptides in a complex mixture.Analytical chemistry · 2010Article
- Influence of charge state and amino acid composition on hydrogen transfer in electron capture dissociation of peptides.Journal of the American Society for Mass Spectrometry · 2010Article
- Mapping N-terminus phosphorylation sites and quantitation by stable isotope dimethyl labeling.Journal of the American Society for Mass Spectrometry · 2010Article
- Electron capture dissociation mass spectrometry of tyrosine nitrated peptides.Journal of the American Society for Mass Spectrometry · 2010Article
- Electron capture dissociation product ion abundances at the X amino acid in RAAAA-X-AAAAK peptides correlate with amino acid polarity and radical stability.Journal of the American Society for Mass Spectrometry · 2009Article
- Periodic sequence distribution of product ion abundances in electron capture dissociation of amphipathic peptides and proteins.Journal of the American Society for Mass Spectrometry · 2009Article
- Infrared photoactivation reduces peptide folding and hydrogen-atom migration following ETD tandem mass spectrometry.Angewandte Chemie (International ed. in English) · 2009Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We decoupled electron-transfer dissociation (ETD) and collision-induced dissociation of charge-reduced species (CRCID) events to probe the lifetimes of intermediate radical species in ETD-based ion trap tandem mass spectrometry of peptides. Short-lived intermediates formed upon electron transfer require less energy for product ion formation and appear in regular ETD mass spectra, whereas long-lived intermediates require additional vibrational energy and yield product ions as a function of CRCID amplitude. The observed dependencies complement the results obtained by double-resonance electron-capture dissociation (ECD) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and ECD in a cryogenic ICR trap. Compared with ECD FT-ICR MS, ion trap MS offers lower precursor ion internal energy conditions, leading to more abundant charge-reduced radical intermediates and larger variation of product ion abundance as a function of vibrational post-activation amplitude. In many cases decoupled CRCID after ETD exhibits abundant radical c-type and even-electron z-type ions, in striking contrast to predominantly even-electron c-type and radical z-type ions in ECD FT-ICR MS and especially activated ion-ECD, thus providing a new insight into the fundamentals of ECD/ETD.
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