Evidence map›Paper›PMID 19111873›Full record

ArticleCancer cell2009

The metastasis problem gets stickier.

Lawrence N Kwong, Lynda Chin

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The multifaceted role of MTDH/AEG-1 in cancer progression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lawrence N KwongDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Lynda Chin

Funding

The genetic Basis of Melanoma MetastasisR01CA093947 · NCI · DANA-FARBER CANCER INSTITUTE · PI CHIN, LYNDA · 2002 to 2011
$3.6M
NCI NIH HHS R01 CA093947
6 · The paper itself

Abstract

The enormity and complexity of cancer genome data present significant challenges in downstream validation of novel oncogenes and tumor suppressors. In this issue of Cancer Cell, Hu et al. evaluate candidate oncogenes in a recurrent amplification in poor-prognosis breast cancers. They identify and validate the prometastatic gene metadherin (MTDH) as a key modulator of endothelial adhesion and chemoresistance.

Indexed as

AnimalsBreast NeoplasmsCell AdhesionCell Adhesion MoleculesDrug Resistance, NeoplasmHumansNeoplasm MetastasisPrognosisCell Adhesion Molecules

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.