ReviewCardiology clinics2009
New concepts in atrial fibrillation: neural mechanisms and calcium dynamics.
Review in Cardiology clinics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Pulmonary vein isolation combined with spironolactone or renal sympathetic denervation in patients with chronic kidney disease, uncontrolled hypertension, paroxysmal atrial fibrillation, and a pacemaker.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018Trial
- Serum Lipids, Inflammation, and the Risk of Atrial Fibrillation: Pathophysiological Links and Clinical Evidence.Journal of clinical medicine · 2025Review
- Autonomic Tone Variations Prior to Onset of Paroxysmal Atrial Fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2022Observational
- Atrial Fibrillation (Part 1): Pathophysiology, Risk Factors, and Therapeutic Basis.Arquivos brasileiros de cardiologia · 2021Article
- Synaptic Plasticity in Cardiac Innervation and Its Potential Role in Atrial Fibrillation.Frontiers in physiology · 2018Review
- Atrial Fibrillation: The Science behind Its Defiance.Aging and disease · 2016Review
- Generalized Poincaré Plots-A New Method for Evaluation of Regimes in Cardiac Neural Control in Atrial Fibrillation and Healthy Subjects.Frontiers in neuroscience · 2016Article
- Recent insights into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system.Circulation. Arrhythmia and electrophysiology · 2012Review
- NOX4-Dependent Hydrogen Peroxide Overproduction in Human Atrial Fibrillation and HL-1 Atrial Cells: Relationship to Hypertension.Frontiers in physiology · 2012Article
- Mechanisms of termination and prevention of atrial fibrillation by drug therapy.Pharmacology & therapeutics · 2011Review
- Recent advances in the molecular pathophysiology of atrial fibrillation.The Journal of clinical investigation · 2011Review
- Atrial Fibrillation and Metabolic Syndrome: Understanding the Connection.Journal of atrial fibrillationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Atrial fibrillation (AF) is a complex arrhythmia with multiple possible mechanisms. It requires a trigger for initiation and a favorable substrate for maintenance. Pulmonary vein myocardial sleeves have the potential to generate spontaneous activity, and this arrhythmogenic activity is surfaced by modulation of intracellular calcium dynamics. Direct autonomic nerve recordings in canine models show that simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial tachycardia and paroxysmal AF. Autonomic modulation as a potential therapeutic strategy has been targeted clinically and experimentally, but its effectiveness as an adjunctive therapeutic modality to catheter ablation of AF has been inconsistent. Further studies are warranted before application can be widely implied for therapies of clinical AF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.