Evidence map›Paper›PMID 19111194›Full record

ArticleMethods in enzymology2008

Cell biology of mRNA decay.

David Grünwald, Robert H Singer, Kevin Czaplinski

Abstract read
In one paragraph

Article in Methods in enzymology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.Journal of experimental & clinical cancer research : CR · 2016
    Article
  2. RNA detection in situ with FISH-STICs.RNA (New York, N.Y.) · 2014
    Article
  3. mRNA on the move: the road to its biological destiny.The Journal of biological chemistry · 2013
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. A perspective of the dynamic structure of the nucleus explored at the single-molecule level.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011
    Review
  10. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
  11. Article
  12. Single mRNA tracking in live cells.Methods in enzymology · 2010
    Article
  13. Not all quiet on the noise front.Nature chemical biology · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David GrünwaldAlbert Einstein College of Medicine, Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Bronx, Albert Einstein College of Medicine, New York, USA.
Robert H Singer
Kevin Czaplinski

Funding

Mechanism of Actin mRNA LocalizationR01GM084364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2008 to 2012
$1.9M
NIGMS NIH HHS R01 GM084364
6 · The paper itself

Abstract

Studying single mRNA molecules has added new dimensions to our understanding of gene expression and the life cycle of mRNA in cells. Advances in microscopes and detection technology have opened access to single molecule research to most researchers interested in molecular biology. Here we provide an overview technique for single molecule studies of RNA in either fixed samples or in living cells. As part of a volume on mRNA turnover, it is increasingly relevant, because many of the recent advances in studies of mRNA turnover have suggested that there is non-homogeneous distribution of turnover factors in the cell. For this reason, understanding of spatial relationships between mRNA and mRNA turnover factors should enrich our understanding of this process.

Indexed as

RNA StabilityAnimalsCell SurvivalHumansIn Situ Hybridization, FluorescenceMicroscopyProteinsRNA, MessengerProteinsRNA, Messenger

Identifiers

PMID19111194
PMCPMC3152983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.