Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2008
CPAP therapy of obstructive sleep apnea in type 2 diabetics improves glycemic control during sleep.
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Effects of continuous positive airway pressure therapy on glycaemic control, insulin sensitivity and body mass index in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2015Pooled it
- Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2013Pooled it
- Pooled it
- Trial
- A Week of Sleep Restriction Does Not Affect Nighttime Glucose Concentration in Healthy Adult Males When Slow-Wave Sleep Is Maintained.Sensors (Basel, Switzerland) · 2022Trial
- Effect of 12-week continuous positive airway pressure therapy on glucose levels assessed by continuous glucose monitoring in people with type 2 diabetes and obstructive sleep apnoea; a randomized controlled trial.Endocrinology, diabetes & metabolism · 2021Trial
- CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure.Sleep & breathing = Schlaf & Atmung · 2017Trial
- Effect of continuous positive airway pressure (CPAP) on glycemic control and variability in type 2 diabetes.Sleep & breathing = Schlaf & Atmung · 2017Trial
- Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes.Chinese medical journal · 2015Trial
- Trial
- Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity.Respiratory research · 2011Trial
- Role of Continuous Positive Airway Pressure in the Prevention of Cardiovascular Events in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis of Randomized Clinical Trials.Journal of the Saudi Heart Association · 2026Review
- Continuous Glucose Monitoring Among People with and without Diabetes Mellitus and Sleep Apnoea.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Review
- Type 2 Diabetes Mellitus and Obstructive Sleep Apnoea Syndrome in the Elderly.Healthcare (Basel, Switzerland) · 2025Article
- Review
- Effect of CPAP on blood glucose fluctuation in patients with type 2 diabetes mellitus and obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Article
- Impact of continuous positive airway pressure ventilation on cardiovascular outcomes among patients with obstructive sleep apnea: A meta-analysis of randomized trials.American heart journal plus : cardiology research and practice · 2021Article
- Clinical profile of patients suspected of sleep apneaRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Article
- Diagnostic accuracy of the Berlin questionnaire and therapeutic effect of nasal continuous positive airway pressure in OSAHS patients with glucose metabolic dysfunction.Sleep & breathing = Schlaf & Atmung · 2021Article
- Rationale and design of the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial.Contemporary clinical trials · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundType 2 diabetes and obstructive sleep apnea (OSA) are frequently comorbid conditions. OSA is associated with increased insulin resistance, but studies of continuous positive airway pressure (CPAP) have shown inconsistent effects on glycemic control. However, endpoints such as hemoglobin A1c and insulin sensitivity might not reflect short-term changes in glycemic control during sleep.
methodsWe used a continuous glucose-monitoring system to measure interstitial glucose every 5 minutes during polysomnography in 20 patients with type 2 diabetes and newly diagnosed OSA. The measurements were repeated after an average of 41 days of CPAP (range 26-96 days). All patients were on a stable diet and medications. Each 30-second epoch of the polysomnogram was matched with a continuous glucose-monitoring system reading, and the sleeping glucose level was calculated as the average for all epochs scored as sleeping.
resultsThe mean sleeping glucose decreased from untreated (122.0 +/- 61.7 mg/dL) to treated (102.9 +/- 39.4 mg/dL; p = 0.03 by Wilcoxon paired rank test). The sleeping glucose was more stable after treatment, with the median SD decreasing from 20.0 to 13.0 mg/dL (p = 0.005) and the mean difference between maximum and minimum values decreasing from 88 to 57 mg/dL (p= 0.003). The change in the mean hemoglobin A1c from 7.1% to 7.2% was not significant.
conclusionsOur study is limited by the lack of a control group, but the results suggest that sleeping glucose levels decrease and are more stable after patients with type 2 diabetes and OSA are treated with CPAP.
Indexed as
Identifiers
19110882PMC2603530W1604056296What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.