ReviewCirculation journal : official journal of the Japanese Circulation Society2009
Novel aspects of oxidative stress in cardiovascular diseases.
Review in Circulation journal : official journal of the Japanese Circulation Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ginsenosides from American ginseng: chemical and pharmacological diversity.Phytochemistry · 2011Pooled it
- Tart cherry juice decreases oxidative stress in healthy older men and women.The Journal of nutrition · 2009Trial
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Protective effects of Apelin-13 on nicotine-induced H9c2 cardiomyocyte apoptosis and oxidative stress.Tobacco induced diseases · 2025Article
- The Focal Induction of Reactive Oxygen Species in Rats as a Trigger of Aortic Valve Degeneration.Antioxidants (Basel, Switzerland) · 2024Article
- Development and evaluation of a liquid chromatography-tandem mass spectrometry method for simultaneous measurement of toxic aldehydes from brain tissue.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024Article
- Albumin Redox Modifications Promote Cell Calcification Reflecting the Impact of Oxidative Status on Aortic Valve Disease and Atherosclerosis.Antioxidants (Basel, Switzerland) · 2024Article
- Review
- Mechanism of Hypercholesterolemia-Induced Atherosclerosis.Reviews in cardiovascular medicine · 2022Review
- The Influence of Coronary Artery Disease in the Development of Aortic Stenosis and the Importance of the Albumin Redox State.Antioxidants (Basel, Switzerland) · 2022Article
- An Integrated Approach Based on Network Analysis Combined With Experimental Verification Reveals PI3K/Akt/Nrf2 Signaling Is an Important Way for the Anti-Myocardial Ischemia Activity ofFrontiers in pharmacology · 2022Article
- The mechanistic pathways of oxidative stress in aortic stenosis and clinical implications.Theranostics · 2022Review
- Article
- Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties.International journal of molecular sciences · 2021Article
- Assessment of Diastolic Function and Thiol-Disulphide Homeostasis in Arsenic-Exposed Workers.Acta Cardiologica Sinica · 2021Article
- Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice.Frontiers in physiology · 2021Article
- Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress.Medicina (Kaunas, Lithuania) · 2019Article
- HgS Inhibits Oxidative Stress Caused by Hypoxia through Regulation of 5-HT Metabolism Pathway.International journal of molecular sciences · 2019Article
- Porphyrin-Based SOD Mimic MnTnBu OE -2-PyPJournal of the American Heart Association · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Oxygen radicals, and other reactive oxygen species, may play an important role in the pathophysiology of atherosclerosis, stroke, and other cardiovascular diseases. Mechanisms that account for oxidative stress in different cardiovascular diseases are diverse; for example, increases in activity of NAD(P)H oxidase, "uncoupling" of nitric oxide synthase, and maladaptive changes in expression of antioxidants can all contribute to increases in oxidative stress. Very different patterns of pro-and antioxidant mechanisms that contribute to increases in oxygen radicals in atherosclerotic plaques, hemorrhagic strokes, and aortic valve stenosis have been observed. A disappointment, in relation to the hypothesis that oxygen radicals contribute to cardiovascular risk, is that many studies indicate that antioxidant vitamins fail to reduce the risk of cardiovascular disease. Better understanding of mechanisms that lead to increases in oxidative stress in different cardiovascular diseases may lead to more effective antioxidant prevention or treatment of diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.