ArticleNeurobiology of disease2009
Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice.
Article in Neurobiology of disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.International journal of molecular sciences · 2022Review
- Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson's disease.Archives of pharmacal research · 2021Review
- Surface functionalization of TiOBiomedical engineering online · 2018Article
- Role of microglia in methamphetamine-induced neurotoxicity.International journal of physiology, pathophysiology and pharmacology · 2017Review
- Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons.Brain structure & function · 2016Article
- Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior.Brain plasticity (Amsterdam, Netherlands) · 2015Review
- Methamphetamine induces low levels of neurogenesis in striatal neuron subpopulations and differential motor performance.Neurotoxicity research · 2014Article
- Cyclooxygenase activity contributes to the monoaminergic damage caused by serial exposure to stress and methamphetamine.Neuropharmacology · 2013Article
- Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression.Journal of neuroinflammation · 2013Article
- Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF.Pharmacology, biochemistry, and behavior · 2013Article
- Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity.International journal of environmental research and public health · 2011Review
- Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice.Brain pathology (Zurich, Switzerland) · 2011Article
- Nucleus accumbens invulnerability to methamphetamine neurotoxicity.ILAR journal · 2011Review
- A dual-hit animal model for age-related parkinsonism.Progress in neurobiology · 2010Review
- Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in mice.Neuroscience research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation, phospho-p38 MAPK activation, and a reduction in glial cell line-derived neurotrophic factor (GDNF) occur in Parkinson's disease. Microglial activation in the substantia nigra and a tyrosine hydroxylase deficit in the striatum of 3-month-old GDNF heterozygous (GDNF(+/-)) mice were previously reported and both were exacerbated by a toxic methamphetamine binge. The current study assessed the effects of minocycline on these methamphetamine-induced effects. Minocycline (45 mg/kg, i.p.x 14 days post-methamphetamine or saline injections) reduced microglial activation and phospho-p38 MAPK in the substantia nigra of saline-treated GDNF(+/-) mice and in methamphetamine-treated wildtype and GDNF(+/-) mice. Although minocycline increased tyrosine hydroxylase-immunoreactivity in GDNF(+/-) mice, it did not attenuate the methamphetamine-induced reduction of tyrosine hydroxylase. The results suggest that neuroinflammation is deleterious to the dopamine system of GDNF(+/-) mice but is not the primary cause of methamphetamine-induced damage to the dopamine system in either GDNF(+/-) or wildtype mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.