ReviewBiochimica et biophysica acta2009
Plasticity of central autonomic neural circuits in diabetes.
Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Multi-organ glucose metabolism alterations in diabetes mellitus: a total-bodyEJNMMI research · 2026Article
- Insulin activates parasympathetic hepatic-related neurons of the paraventricular nucleus of the hypothalamus through mTOR signaling.Journal of neurophysiology · 2025Article
- Central NPFF signalling is critical in the regulation of glucose homeostasis.Molecular metabolism · 2022Article
- Musings on the wanderer: What's new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Assessment of common and differentially expressed proteins between diabetes mellitus and fatty liver disease: a network analysis.Gastroenterology and hepatology from bed to bench · 2021Article
- Understanding the Effects of Antipsychotics on Appetite Control.Frontiers in nutrition · 2021Review
- Fibroblast Growth Factor 19 Increases the Excitability of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice.Frontiers in endocrinology · 2021Article
- Effects of metabolic state on the regulation of melanocortin circuits.Physiology & behavior · 2020Review
- Review
- A hindbrain inhibitory microcircuit mediates vagally-coordinated glucose regulation.Scientific reports · 2019Article
- Functional and molecular plasticity of γ and α1 GABAJournal of neurophysiology · 2017Article
- Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.American journal of physiology. Endocrinology and metabolism · 2016Review
- Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity.Seminars in immunopathology · 2016Review
- Brain stem as a target site for the metabolic side effects of olanzapine.Journal of neurophysiology · 2016Article
- Brain-liver connections: role of the preautonomic PVN neurons.American journal of physiology. Endocrinology and metabolism · 2016Review
- Molecular and functional changes in glucokinase expression in the brainstem dorsal vagal complex in a murine model of type 1 diabetes.Neuroscience · 2015Article
- Glucose sensing by GABAergic neurons in the mouse nucleus tractus solitarii.Journal of neurophysiology · 2015Article
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- Regulation of leptin receptor-expressing neurons in the brainstem by TRPV1.Physiological reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Regulation of energy metabolism is controlled by the brain, in which key central neuronal circuits process a variety of information reflecting nutritional state. Special sensory and gastrointestinal afferent neural signals, along with blood-borne metabolic signals, impinge on parallel central autonomic circuits located in the brainstem and hypothalamus to signal changes in metabolic balance. Specifically, neural and humoral signals converge on the brainstem vagal system and similar signals concentrate in the hypothalamus, with significant overlap between both sensory and motor components of each system and extensive cross-talk between the systems. This ultimately results in production of coordinated regulatory autonomic and neuroendocrine cues to maintain energy homeostasis. Therapeutic metabolic adjustments can be accomplished by modulating viscerosensory input or autonomic motor output, including altering parasympathetic circuitry related to GI, pancreas, and liver regulation. These alterations can include pharmacological manipulation, but surgical modification of neural signaling should also be considered. In addition, central control of visceral function is often compromised by diabetes mellitus, indicating that circuit modification should be studied in the context of its effect on neurons in the diabetic state. Diabetes has traditionally been handled as a peripheral metabolic disease, but the central nervous system plays a crucial role in regulating glucose homeostasis. This review focuses on key autonomic brain areas associated with management of energy homeostasis and functional changes in these areas associated with the development of diabetes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.