ArticleWorld journal of gastroenterology2008
Metrically measuring liver biopsy: a chronic hepatitis B and C computer-aided morphologic description.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Fractal nature of human gastrointestinal system: Exploring a new era.World journal of gastroenterology · 2023Review
- New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.Acta cirurgica brasileira · 2020Article
- The Complexity and Fractal Geometry of Nuclear Medicine Images.Molecular imaging and biology · 2019Review
- Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study.Journal of translational medicine · 2019Article
- A New Image Analysis Method Based on Morphometric and Fractal Parameters for Rapid Evaluation of In Situ Mammalian Mast Cell Status.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2015Article
- Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy.Scientific reports · 2015Article
- Automated morphometry provides accurate and reproducible virtual staging of liver fibrosis in chronic hepatitis C.Journal of pathology informatics · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo describe a quantitative analysis method for liver biopsy sections with a machine that we have named "Dioguardi Histological Metriser" which automatically measures the residual hepatocyte mass (including hepatocytes vacuolization), inflammation, fibrosis and the loss of liver tissue tectonics.
methodsWe analysed digitised images of liver biopsy sections taken from 398 patients. The analysis with Dioguardi Histological Metriser was validated by comparison with semi-quantitative scoring system.
resultsThe method provides: (1) the metrical extension in two-dimensions (the plane) of the residual hepatocellular set, including the area of vacuoles pertinent to abnormal lipid accumulation; (2) the geometric measure of the inflammation basin, which distinguishes intra-basin space and extra-basin dispersed parenchymal leukocytes; (3) the magnitude of collagen islets, (which were considered truncated fractals and classified into three degrees of magnitude); and (4) the tectonic index that quantifies alterations (disorders) in the organization of liver tissue. Dioguardi Histological Metriser machine allows to work at a speed of 0.1 mm(2)/s, scanning a whole section in 6-8 min.
conclusionThe results are the first standardized metrical evaluation of the geometric properties of the parenchyma, inflammation, fibrosis, and alterations in liver tissue tectonics of the biopsy sections. The present study confirms that biopsies are still valuable, not only for diagnosing chronic hepatitis, but also for quantifying changes in the organization and order of liver tissue structure.
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